Clinical Trials Logo
  1. Home
  2. Post-Operative Delirium
  3. NCT02692300

EEG Guidance of Anesthesia (ENGAGES-CANADA) — ENGAGES  

Post-operative Delirium Clinical Trial

Official title:
Protocol for the Electroencephalography Guidance of Anesthesia to Alleviate Geriatric Syndromes (ENGAGES-CANADA) Study: a Pragmatic, Randomized Clinical Trial

Clinical Trial Summary

This study examines the potential link between deep levels of anesthesia and delirium.

Clinical Trial Description

ENGAGES CANADA is a parallel study to the ENGAGES study which has been published in JAMA, DOI:10.1001/jama.2019.5161. Due to the difference in practice models and types of anesthesia principles, ENGAGES CANADA is an important study. Delirium is a relatively common postoperative complication in the geriatric population, affecting 20% to 70% of surgical patients over the age of 60. Delirium manifests as confusion, inattention and the inability to think logically, and may affect the patient's postoperative healing and rehabilitation. It is associated with persistent cognitive decline, longer hospital stay, increased incidence of injurious falls, and increased mortality. Patients undergoing major cardiac surgery are at a significant risk of postoperative delirium. To date, there is no proven method to prevent postoperative delirium in this patient population and often delirious events remain unrecognized. Randomized controlled studies in diverse surgical patient populations suggest that intraoperative electroencephalography (EEG) guidance during general anesthesia may decrease postoperative delirium and adverse postoperative outcomes. Patients who experience postoperative delirium report persistently decreased quality of life and it is a risk factor for incident psychiatric disorders and psychotropic medication use. One potential key mechanism in the relationship between delirium and incident psychiatric illness may be the experience of dissociation (disturbed awareness, impaired memory, or altered perceptions) in the perioperative period in those who are delirious. The co-occurrence of psychiatric illness and delirium can put older adults at greater risk of negative long terms effect such as functional decline. This study will compare the effectiveness of two anesthetic protocols in reducing postoperative delirium and postoperative health-related quality of life in a high risk population.We expect that EEG-guided anesthetic management of patients during their operative procedure will result in improved health-related outcomes, specifically decreased incidence of postoperative delirium and improved postoperative mental and physical health outcomes. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02692300
Study type Interventional
Source University of Manitoba
Contact
Status Completed
Phase N/A
Start date December 28, 2016
Completion date February 24, 2023
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT06028126 - Superficial Parasternal Intercostal Plane Block in Cardiac Surgery Trial N/A
Not yet recruiting NCT05877326 - Anaesthetic Depth and Short Term Delirium Post Cardiac Surgery Intervention N/A
Terminated NCT00991328 - Role of Absolute Cerebral Oximetry to Prevent Neurocognitive Injury in Elderly Patients Undergoing Cardiac Surgery Phase 3
Active, not recruiting NCT03785158 - MIND After Surgery N/A
Recruiting NCT06236854 - Neuroimaging Risk of Postoperative Delirium
Completed NCT00250237 - Post-operative Haloperidol Versus Placebo for Prevention of Post-operative Delirium After Acute Hip Surgery Phase 3
Completed NCT03953313 - Risk Communication About Post-operative Delirium (POD) and Post-operative Cognitive Dysfunction (POCD)
Recruiting NCT05887076 - Postoperative Delirium After Kidney Transplantation
Recruiting NCT05777187 - Mitigation of Postoperative Delirium in High-Risk Patients N/A
Recruiting NCT05688449 - Effect of Epidural Analgesia on Burst Suppression Phase 4
Completed NCT00791648 - Short-term Atorvastatin's Effect on Acute Kidney Injury Following Cardiac Surgery N/A
Completed NCT03132168 - Postoperative Delirium in Patients Undergoing Radical Cystectomy N/A
Completed NCT02325154 - Cerebral Oxygenation in Total Hip Arthroplasty Patients N/A
Active, not recruiting NCT01993992 - Parental Anxiety and Its Relationship With Pediatric Patients' Post-operative Responses N/A
Completed NCT00865202 - A Placebo Controlled Trial Of L-Tryptophan In Post-Operative Delirium Phase 3
Completed NCT05159648 - A Study to Evaluate ICU Simulation Experience in the Cardiothoracic Surgical Population to Reduce Post-operative Delirium
Completed NCT01561378 - Cardiac Surgery Neuroprotection Study in Elders Phase 2
Recruiting NCT06036095 - Total Intravenous Versus Inhalational Anesthesia- A Geriatric Anesthesia Study Phase 4
Completed NCT03053869 - Benzodiazepine-free Anesthetic for Reduction of Delirium (B-Free) Phase 1