A Placebo Controlled Trial Of L-Tryptophan In Post-Operative Delirium

Status Completed

Clinical Trial Summary

Post-operative delirium is a common and deleterious complication in elderly patients. The investigators have previously found lower levels of serum tryptophan in post-operative elderly patients who developed delirium in comparison to post-operative elderly patients who did not develop delirium. The investigators hypothesize that post-operative supplementation of L-tryptophan will reduce the duration and incidence of post-operative delirium. This study is a double-blinded placebo controlled trial of L-tryptophan supplementation in post-operative ICU patients 60 years and older. The primary outcome measure is the comparison of duration of post-operative delirium in subjects who receive L-tryptophan supplementation versus a similar appearing control.

Clinical Trial Description

The sudy will compare rates and duration of postoperative delirium in groups that receive L-tryptophan supplementation compared to placebo. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00865202
Study type	Interventional
Source	University of Colorado, Denver
Contact
Status	Completed
Phase	Phase 3
Start date	December 2008
Completion date	December 2012

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