Post-operation Delirium Clinical Trial
Hypothesis is that the presence of a-synucleinopathy related non motor symptoms could be predictive factor for post-operative delirium. During 72hrs after spine surgery, investigator will observe occurrence of post-operative delirium, and analysis difference of a-synucleinopathy related non motor symptoms between 2 groups.
Postoperative delirium appear approximately 10-70% of patients older than 65 yrs undergoing
surgery and it is strongly associated with poor surgical outcome. The clinical
characteristics of postoperative delirium are fluctuating attention, visual hallucination,
disorganized thought and alter sleep-wake cycles. This is quite similar to core features of
α-synuclein-related cognitive disorders such as parkinson`s disease dementia and dementia
with lewy body. At that point, investigator thought that postoperative delirium is
preclinical stage of a-synucleinopathy. In other words, a-synuclein related disorders and
postoperative delirium may share an underlying neurochemical change in their pathogenesis.
investigator will recruit age 65 and older patients scheduled to perform spine surgery. The pre-operative evaluation include neurologic exam, baseline cognitive function and a-synucleinopathy related non motor symptoms through Questionnaires. ;
|Start date||October 2015|
|Completion date||August 2016|