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Post Menopausal clinical trials

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NCT ID: NCT06166264 Recruiting - Post Menopausal Clinical Trials

Effects of Progressive Resistance Training Vasomotor Symptoms in Post Menopausal Women

Start date: April 5, 2023
Phase: N/A
Study type: Interventional

The study will be a randomized clinical trial and will be conducted in Civil Hospital and Kalsoom Hospital Samundry. This study will be completed in time duration of 10 months after the approval of synopsis. Non probability convenience sampling with Randomization technique will be used and 26 participants will be recruited in study after randomization. The subjects will be divided into two groups and the group A will receive Progressive training and Health education and group B will receive only Health education. The data will be assessed at the baseline and after 8th week of treatment. After data collection data will be analyzed by using SPSS version 21.

NCT ID: NCT05810974 Not yet recruiting - Post Menopausal Clinical Trials

The Impact of Inorganic Nitrate-rich Beetroot Juice on Microvascular Blood Flow and Cognitive Function

Start date: April 14, 2023
Phase: N/A
Study type: Interventional

Cardiovascular disease (CVD) is one of the leading causes of mortality worldwide. Inorganic nitrate found in beetroot and green leafy vegetables has been demonstrated to reduce cardiovascular disease risk factors including reducing blood pressure and the stiffness of blood vessels by increasing levels of a compound called nitric oxide. Much of the research to date has focused on the large blood vessels, and little is known about the impact of inorganic nitrate on smaller blood vessels which could be related to cognitive function. The majority of beneficial effects with inorganic nitrate have been observed within young healthy populations. However, it is known that after the menopause women are at an increased risk of cardiovascular disease and have reduced levels of nitric oxide in their body; this could also contribute to the cognitive decline also observed post-menopause. This trial will investigate the impact of inorganic nitrate from beetroot juice on the blood flow in small blood vessels and on cognitive function in postmenopausal women. The hypothesis of the study is that the nitrate in beetroot juice will increase circulating nitric oxide that will then increase blood flow in small blood vessels and improve cognitive function.

NCT ID: NCT03981341 Recruiting - Oxidative Stress Clinical Trials

Impact of Estrogen + Estradiol Receptor Alpha Modulator Therapy on Oxidative Stress in Post-menopausal Women With and Without Sleep Apnea

Alpha MenoX
Start date: November 1, 2019
Phase: Phase 3
Study type: Interventional

One of the most likely mechanisms explaining the sleep apnea (SA)-induced increase in metabolic syndrome is the oxidative stress (OS) induced by intermittent hypoxia (IH). There are clear-cut signs of OS in postmenopausal women that may be further enhanced by SA. In rats exposed to IH, an estradiol receptor alpha agonist decreases the level of OS markers. The aims of this study are to compare OS in apneic and non-apneic postmenopausal women and to demonstrate that OS will improve after 3 months of treatment with ER alpha agonists (Duavive) in apneic post-menopausal women.

NCT ID: NCT03036722 Recruiting - Post Menopausal Clinical Trials

Flaxseed Consumption and Bone Metabolism in Postmenopausal Women.

FLAX
Start date: May 10, 2017
Phase: N/A
Study type: Interventional

This proposed randomized double blinded, placebo-controlled, parallel trial; with two arms, in females aged 50-70 years, volunteers will be postmenopausal with a BMI between 25-35 kg/m2. This study aims to determine the benefits of phytoestrogen-rich flaxseeds on decreasing bone turnover in postmenopausal women aged over 50 years.

NCT ID: NCT01443455 Completed - Post Menopausal Clinical Trials

Adherence and Health Effects of Video Dance in Postmenopausal Women

Start date: January 2010
Phase: N/A
Study type: Interventional

This is a 6 month randomized clinical trial comparing video dance, brisk walking and delayed entry controls. The interventions have two phases; a 12 week initiation phase with substantial structure and supervision, followed by a 12 week transition phase, with reduced structure and supervision. Participants are 168 overweight or obese, sedentary postmenopausal women aged 50 to 65; 60 in each exercise arm and 48 in the wait list control group. The following research questions will be assessed: 1. Is exercise adherence at 6 months better with video dance games compared to brisk walking? 2. Does video dance game exercise compared to wait list controls, induce beneficial changes in physical and mental health? 3. Does video dance game exercise compared to brisk walking better promote balance, attention and visual spatial skills, without loss of benefit to cardiovascular fitness? 4. Is video dance preferred to brisk walking for exercise among postmenopausal women? If so, who and why?

NCT ID: NCT00884143 Completed - Breast Cancer Clinical Trials

Observational Triveneto Study on the Use of Adjuvant Hormonal Therapies in the Treatment of Hormone-responsive Breast Cancer

TIME 2 CHANGE
Start date: July 2009
Phase: N/A
Study type: Observational

There are different types of hormonal therapy medicines for the treatment of hormone-receptor-positive breast cancer. The purpose of this study is to determine the evolution of two types of hormonal treatment (the drug called "tamoxifen" and a group of medicines called "aromatase inhibitors") during two time periods of 12 months each, in years 2006 and 2008, in the northeast Italian regions. The study will include post-menopausal women who have initiated hormonal therapy medicines in 2006. The study will also verify the rate of implementation of the updated national and international recommendations for the use of adjuvant hormonal therapy in the hormone-receptor-positive breast cancer.

NCT ID: NCT00660244 Completed - Arthralgia Clinical Trials

Breast Cancer Tumor Care Observational Programme

Start date: February 2008
Phase: N/A
Study type: Observational

The purpose of this study is to investigate efficacy and tolerability under anastrozole (Arimidex) treatment.

NCT ID: NCT00280930 Active, not recruiting - Breast Cancer Clinical Trials

Letrozole in Postmenopausal Women at Increased Risk for Breast Cancer

Start date: October 2005
Phase: Phase 2
Study type: Interventional

The purpose of this study to see what happens to breast density in healthy postmenopausal women after treatment with letrozole in one year, compared with treatment with placebo for one year. Other goals of the study include determining if there is a connection between estrogen level and breast density for women in the study and collecting information about the quality of life of those taking part in the study.

NCT ID: NCT00060736 Completed - Healthy Clinical Trials

The Effects of Estrogen Withdrawal on Mood Symptoms in Women

Start date: May 5, 2003
Phase:
Study type: Observational

This study evaluates the effects on mood when stopping estrogen replacement therapy. The purpose of this study is to investigate the effects of estrogen levels on perimenopausal depression. This study will examine short-term withdrawal of estrogen in women whose mood had improved with estrogen therapy. Perimenopause-related mood disorders cause significant distress in a large number of women. Evidence suggests that estradiol may have beneficial effects in women with perimenopausal depression. However, the effect of declining estradiol secretion during perimenopause has not been fully examined. Peri- and post-menopausal women who experience a remission of perimenopause-related depression symptoms while on estrogen therapy and a control group of healthy volunteers on hormone replacement therapy (HRT) will be switched from their current form of HRT to estradiol for a 3-week period; volunteers will also complete symptom ratings to confirm the absence of mood symptoms. Participants will then be randomly assigned to either continue estradiol or take a placebo (an inactive pill) for an additional 3 weeks. Mood ratings will be used to determine response to estradiol withdrawal. ...