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Post Lung Transplantation clinical trials

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NCT ID: NCT04093869 Active, not recruiting - Clinical trials for Post-Lung Transplantation

Improving Lung Transplant Outcomes With Coping Skills and Physical Activity

INSPIRE-III
Start date: November 6, 2019
Phase: N/A
Study type: Interventional

This study evaluates the effectiveness of a coping skills and exercise (CSTEX) intervention among post lung transplant patients aimed to reduce distress and improve functional capacity. Half of the patients will receive CSTEX and half will receive the standard of care plus transplant education (SOC-ED).

NCT ID: NCT02631720 Completed - Lung Transplant Clinical Trials

CLAD Phenotype Specific Risk Factors and Mechanisms

Start date: December 22, 2015
Phase:
Study type: Observational

While many patients experience benefits from transplant, complications such as infections and lung rejection may affect long term survival and quality of life. In this study doctors are looking at a complication called Chronic Lung Allograft Dysfunction (CLAD). CLAD is thought to be chronic rejection of the lung by the immune system and is the leading cause of death after lung transplantation. The purpose of this study is to help doctors determine: - why some people get CLAD and others do not - how patients who get CLAD do after CLAD is diagnosed - how CLAD may affect quality of life

NCT ID: NCT00177827 Completed - Clinical trials for Post Lung Transplantation

Voriconazole Prophylaxis Against Aspergillosis in Lung Transplant Recipients

Start date: March 2004
Phase: Phase 4
Study type: Observational

A fixed dosage regimen of voriconazole is routinely used for prophylaxis of aspergillosis in lung transplant patients at our institution. We hypothesize that use of a fixed dosage voriconazole regimen leads to large degree of variability in drug exposure among lung transplant patients and consequently, therapeutic failures or toxicity. This is a three part study which will examine plasma and lung voriconazole concentrations achieved with the prophylactic regimen and assess for a correlation between these concentrations with efficacy and toxicity. We aim to conduct an initial pilot study in 12 lung transplant patients to characterize the pharmacokinetic profile of voriconazole with both intravenous and oral doses. The data gathered from the pilot pharmacokinetic study will then be utilized to correlate trough concentrations with total voriconazole drug exposure as measured by area under the plasma concentration versus time curve (AUC). Additionally, trough concentrations will be followed over nine weeks of the prophylactic treatment period in a larger cohort of patients to determine maintenance of consistency in trough concentrations and whether the plasma concentrations are predictive of efficacy and toxicity. Voriconazole lung concentrations will be measured in a pilot study of 12 patients who undergo a bronchoscopy procedure as part of their standard medical care in order to determine the relationship between plasma and lung concentrations. The information obtained from this three phase study will be utilized to characterize the pharmacokinetics of voriconazole in lung transplant patients. Further, it will be used to define an optimal therapeutic voriconazole regimen that will be individualized to target specific concentrations in the lung and plasma to maximize efficacy and minimize toxicity