Pneumonia Clinical Trial
Official title:
Role of Chest Ultrasound in Diagnosing and Follow-up of Pneumonia. Prospective Comparison Between X-ray Chest Film in Two Planes and "Low-dose" Spiral Computed Tomography
The study of a large number of patients (at least 200 patients) from several European
centres aims to investigate the value of chest ultrasound in diagnosing and checking the
course of pneumonia as compared to a chest X-ray film in two planes and - in case of a
controversial X-ray finding- as compared to low-dose CT.
An X-ray finding is regarded controversial, if infiltrates cannot be reliably excluded or
not reliably represented and if a definite diagnosis is, thus, not possible. A low-dose CT
is indicated even in case of a positive chest ultrasound and negative X-ray finding.
Sonographic recording and characterization of pneumonic infiltrates is performed both at the
time of diagnosing and in the further course under therapy.
The primary target criterion is
• Assessing the sensitivity of chest ultrasound in diagnosing pneumonia.
Secondary target criteria comprise
- Assessing specificity, negative and positive predictive value of chest ultrasound at
the time of diagnosing,
- Characterizing pneumonic infiltrates at the time of diagnosing and further course,
- Describing the association between clinical, X-ray and sonographic findings in the
course of pneumonia.
The tertiary target criterion includes
• Characterizing the range of pathogens detected by microbiological examination.
;
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