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Clinical Trial Summary

This open-label randomised controlled clinical trial will compare the safety, tolerability, therapeutic efficacy and pharmacokinetics and pharmacodynamics of arterolane-piperaquine, arterolane-piperaquine plus mefloquine versus artemether-lumefantrine.in children with uncomplicated falciparum malaria in Kilifi, Kenya. This study will also provide an up to date insight on the current presence of antimalarial resistance in this site.

In addition, all children will be treated with a single low dose of primaquine, dosing is age based.

The investigators will recruit 219 patients aged 2 years to 12 years with acute uncomplicated falciparum malaria in Kilifi County Hospital.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT03452475
Study type Interventional
Source University of Oxford
Contact Rob van der Pluijm, Dr
Phone +66-02-203-6333
Email Rob@tropmedres.ac
Status Not yet recruiting
Phase Phase 3
Start date March 10, 2018
Completion date December 1, 2020

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