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Activity To Improve Outcomes in Peripheral Arterial Disease — ACTION  

Peripheral Arterial Occlusive Disease Clinical Trial

Official title:
Activity To Improve Outcomes in Peripheral Arterial Disease

Clinical Trial Summary

Peripheral artery disease (PAD) results in blockages of arteries (blood vessels) in the legs and decreased blood flow to the legs. This may cause difficulty or pain with walking or other activities that use leg muscles. Exercise may help improve blood flow in the legs and improve the ability to walk. This research project is being implemented in adults with PAD to examine the effects of exercise or weight loss programs on lower extremity blood flow, health, and physical function.

Clinical Trial Description

This pilot study seeks to gather data on different exercise interventions in PAD. Collectively, the proposed studies will gather data on the role of novel exercise interventions in those with PAD who are receiving conservative treatment as well as those who have undergone an endovascular intervention for lower extremity arterial disease. We hypothesize that patients who undergo an exercise intervention will: A) show improved lower extremity perfusion and B) improve their functional ability, compared to a standard care control group over 6 months of follow-up. We further hypothesize that these improvements are mediated through angiogenesis and increased perfusion of the lower limb, as well as improvements in muscle strength, mass, and function. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02189018
Study type Interventional
Source Baltimore VA Medical Center
Contact
Status Completed
Phase N/A
Start date August 2014
Completion date July 4, 2023
View Details
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