Periodontitis Clinical Trial
Official title:
Photoablative-photodynamic (PAPD) Diode Laser Therapy Adjunctive to Scaling and Root Planing in Periodontitis
The purpose of this study is to compare the efficacy of photoablative and photodynamic diode laser in adjunct to scaling-root planing (PAPD+SRP) and SRP alone for the treatment of periodontitis.
The present study is a randomized, blinded, controlled clinical trial, which used a
split-mouth design. All patients were informed individually about the nature of the proposed
treatment, and informed consent forms were signed. Twenty-four patients were studied.
Maxillary left or right quadrants were randomly assigned to PAPD laser treatment or
sham-treatment and SRP. PAPD consisted of: i) photoablative gingival epithelium with diode
laser (λ 810 nm, 1 W); ii) photodynamic treatments (4-10 weekly) with diode laser (λ 635 nm,
100 mW) and 0.3% methylene blue as photoactive antiseptic, performed after SRP.
Sham-treatment was similar but with switched off laser.
Efficacy evaluations, including probing depth (PD), clinical attachment level (CAL), bleeding
on probing (BOP) was performed at baseline ,1year, and year 3 using a conventional manual
periodontal probe. Polymorphonuclear leukocytes (PMN), erythrocytes (RBC), damaged epithelial
cells (DEC) and bacteria were assayed by cytofluorescence on gingival exfoliative samples at
baseline, 6 month and 1, 3, 5 years.
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