Visfatin Levels Before and After Periodontal Treatment

Periodontal Diseases Clinical Trial

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Official title:

Gingival Crevicular Fluid and Serum Levels of Visfatin in Periodontal Diseases Before and After Non-surgical Periodontal Treatment

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02615626
• Other study ID #: VLandPT
• Status: Completed
• Phase: N/A
• First received: November 23, 2015
• Last updated: November 24, 2015
• Start date: May 2012
• Est. completion date: January 2014

Study information

• Verified date: November 2015
• Source: Bulent Ecevit University
• Contact: n/a
• Is FDA regulated: No
• Health authority: Turkey: Ethics Committee
• Study type: Observational

Clinical Trial Summary

The purpose of this study was to evaluate visfatin levels in different stages of periodontal diseases and health, moreover the effect of non-surgical periodontal therapy on visfatin levels in Gingival Crevicular Fluid (GCF) and Serum.

Description:

Total of 45 patients were divided into three groups based on their clinical and radiographical examination. Group 1 chronic periodontitis (n: 15), group 2 plaque induced gingivitis (n: 15) and group 3 Periodontal health (n: 15). GCF and serum samples were collected before treatment and 1, 3, 6 months after treatment and were assayed using enzyme linked immunosorbent assay kit.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 45
• Est. completion date: January 2014
• Est. primary completion date: October 2013
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 25 Years to 49 Years

Eligibility

Group 1 Inclusion Criteria:

• GI>1, PPD=5mm, CAL=5mm with alveolar bone loss radiographically.

• Systematically healthy patients

Group 2 Inclusion Criteria:

• No alveolar bone and attachment loss

• Inflammation signs such as redness, edema and increased BOP levels,

• GI=2, PPD=3mm, CAL=3mm.

• Systematically healthy patients

Group 3 Inclusion Criteria:

• No bone and attachment loss,

• GI=0, PPD=3mm, CAL=3mm

• Systematically healthy patients

Exclusion Criteria for all groups:

• Aggressive Periodontitis,

• Oral pathologies,

• Patients with any other systemic diseases,

• Pregnant women and those in the lactation period,

• Patients with smoking habit and taking medication

• Patients received periodontal therapy in last 6 months

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Gingival Diseases
• Periodontal Diseases

Intervention

Procedure:
• Non-surgical Periodontal Treatment.
Non-surgical periodontal therapy is an anti-infective therapy which includes both mechanical and chemotherapeutic approaches to minimize or eliminate microbial biofilm, the primary etiology of gingivitis and periodontitis

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Bulent Ecevit University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Visfatin levels: Change after periodontal treatment both in serum and GCF		baseline, 1, 3 and 6 months	Yes