Periodontal Disease Clinical Trial
The treatment of otolaryngology (OLR) cancer is based on surgery, radiation, sometimes used
in combination with chemotherapy. Patients treated with radiotherapy have multiple oral
diseases: mucositis, hyposalivation, tissue fibrosis, exacerbation of periodontitis. Over
70% of patients with head and neck cancers treated with radiotherapy have a lower level of
dental clinical attachment and 92% have loose teeth or missing. The management of these oral
complications is a priority in OLR oncology. The aim is to improve the oral health of
patients to achieve a comfortable life acceptable and necessary for healing.
This project proposes to deepen the investigation with two main objectives:
1. To study in vivo the effect of radiation treatment on the evolution of the viral flora
of the periodontium in a cohort of patients and matched controls.
2. To study in vitro the effects of irradiation on the replication EBV (herpesvirus) in
producing websites lymphoepithelial tonsillar, and atypical dendritic cells associated
with EBV that existence were recently discovered.
n/a
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
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