Percutaneous Coronary Intervention Clinical Trial
Official title:
Contemporary Clinical Treatment and Long-term Outcomes in Patient With Coronary Chronic Total Occlusion:"Time" is the Success Rate of PCI
In order to know more about contemporary clinical treatment ,epidemiological characteristics, and long-term outcomes in patients with Coronary Chronic Total Occlusion(CTO)in China, the study through collecting and effective analyzing basic information, cardiovascular characteristics, contemporary clinical treatment , and long-term outcomes of CTO patients ,to describe the relevant risk factors ,the contemporary incidence of CTOs and the success rates of CTO percutaneous coronary intervention (PCI), as well as the complications and long-term outcomes of these patients, to explore the relevant factors which affecting the success rates of PCI therapy and to provide safer and more effective advice for the treatment of CTO.
Study Center : Shanghai Zhongshan Hospital
Study Purpose : Through collecting and effective analyzing basic information, cardiovascular
characteristics, contemporary clinical treatment , and long-term outcomes of CTO patients ,to
describe the relevant risk factors ,the contemporary incidence of CTOs and the success rates
of CTO percutaneous coronary intervention (PCI), as well as the complications and long-term
outcomes of these patients, to explore the relevant factors which affecting the success rates
of PCI therapy and to provide safer and more effective advice for the treatment of CTO.
Study Design : A Retrospective Observational Study
Study Population Description : All CTO patients who has been diagnosed by coronary
angiography in Shanghai Zhongshan Hospital in 2016-08-01 to 2020-12-31
Eligibility Criteria :
Entry Criteria :
1. Age ≥17 years old;
2. Finished coronary angiography(CAG) in Shanghai Zhongshan Hospital;
3. CAG found coronary artery(-ies) was/were total occluded more than 3 months;
4. CAG found the diameter of total occluded coronary artery was more than 2.5cm;
Exclude Criteria:
1. Cardiac arrest; Ventricular fibrillation; Cardiogenic shock; Acute thrombosis in the
stent; Acute coronary syndrome;
2. The bridge vessel(-s) was/were not total occluded and coronary artery(-ies) was/were
total occluded but not trying to revascularize in CAG of the patient who has gone
through coronary artery bypass graft before;
3. The diameter was too small or position was too distal of the total occluded coronary
artery;
4. Combined severe hepatic or renal insufficiency;
5. The patient who has history of major surgical, cerebral hemorrhage, severe
gastrointestinal bleeding, severe anemia, severe allergies, and other anti-platelet drug
contraindications in recent 3 months;
6. Pregnant, lactating women;
7. Suffer from malignant tumor or life expectancy less than 2 years
Sample size :
Collecting all cases of CTO patient who has been diagnosed in 2016-08-01 to 2020-12-31 and
comply with entry and exclude standards, the expectation of quantity is about 3000-4000.
Follow up time: 2 years
Information collection:
1. Basic information: name, gender, age, hospital number, contact information;
2. Relevant risk factors: medication history, smoking history, drinking history, history of
hypertension, history of diabetes, history of dyslipidemia, history of arrhythmia,
history of cerebrovascular disease, history of renal insufficiency, previous coronary
CTA, and previous myocardial infarction, previous PCI and time, previous CABG surgery
and time;
3. Cardiovascular information: Preoperative and postoperative BNP, preoperative and
postoperative cTnT, cardiac ultrasonography and LVEF, total occluded coronary artery,
collateral circulation establishment, J-CTO score, Progress score, PCI operation mode,
contrast agent usage, and final treatment plan;
4. Follow-up content: short-term results (perioperative-related complications) and 2-year
long-term results (cardiac and LVEF, cardiac death, re-hospitalization of acute
myocardial infarction, and subsequent CABG surgery)
;
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