Neuro-cognitive Impact of Juvenile Obesity

Status Recruiting

Clinical Trial Summary

Recent studies indicate that obese teenagers exhibit memory disturbances. Adolescence represents a crucial period in the development of the hippocampus and the amygdala, necessary for the implementation of memory and emotional functions for the rest of life. Disturbances of the interaction between amygdala and hippocampus during adolescence have been associated with the development of neuropsychiatric disorders. However, the impact of juvenile obesity on functional amygdala-hippocampus connectivity has not been evaluated yet. The main objective of this study is to compare the emotional memory performance and the level of functional connectivity between the hippocampus and the amygdala during the realization of an emotional associative memory task, in obese and control adolescents.

Clinical Trial Description

Obesity increases the prevalence of cognitive impairment. In particular, it can promote disturbances of contextual memory dependent on the hippocampus. Obesity is also associated with negative emotional consequences. However, no clinical study has so far evaluated the effect of obesity on emotional memory, a function underpinned by the amygdala. Recent studies indicate that obese children and adolescents exhibit memory disturbances. Adolescence represents a crucial period in the development of the hippocampus and the amygdala, two brain regions implicated in memory and emotional functions for the rest of life. Changes in connectivity during development, whether structural or functional, are major before the age of 10 and progressive and minor until the age of 30. Disturbances of this amygdala-hippocampal functional connectivity during adolescence have been associated with the development of neuropsychiatric disorders. However, the impact of childhood obesity on functional amygdala-hippocampus connectivity has still not been evaluated. The first aim of the study is to compare the functional connectivity of the hippocampus and the amygdala measured during the realization of an emotional associative memory task or at rest before and after the task between obese teenagers and control teenagers and how closely it is related to emotional memory performances. Secondly, it will be determined whether the level of functional connectivity between the hippocampus and the amygdala is related to cognitive performances and eating symptomatology in obese teenagers. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03776513
Study type	Interventional
Source	University Hospital, Bordeaux
Contact	Pascal BARAT, MD, PhD
Phone	05-56-79-54-45
Email	pascal.barat@chu-bordeaux.fr
Status	Recruiting
Phase	N/A
Start date	December 12, 2018
Completion date	December 12, 2020

View Details

See also
Status	Clinical Trial	Phase
Not yet recruiting	`NCT03994419` - PErioperAtive CHildhood ObesitY
Recruiting	`NCT06111040` - Nurturing Needs Study: Parenting Food Motivated Children	N/A
Completed	`NCT03036696` - The BEACH Interview Study- Pregnant and Breastfeeding Mothers
Not yet recruiting	`NCT02484612` - Exercise Intensity and Appetite in Adolescents	N/A
Completed	`NCT02959034` - Pediatric Metabolism and Microbiome Repository
Completed	`NCT02545764` - Training Induced Reduction of Lower-limb Joint Loads During Locomotion in Obese Children	N/A
Recruiting	`NCT02426346` - A Scalable Weight Control Intervention for Adolescents	Phase 2
Completed	`NCT01989065` - Healthy Lifestyles Program for You (HLP4U): Augmenting Childhood Obesity Treatment.	N/A
Completed	`NCT02160847` - Development of the DRIVE Curriculum to Address Childhood Obesity Risk Factors	N/A
Completed	`NCT02343588` - A National School-based Health Lifestyles Interventions Among Chinese Children and Adolescents Against Obesity	N/A
Completed	`NCT01908153` - Taste Reward Processing in Pediatric Obesity
Completed	`NCT02375490` - Healthy Start to Increase Physical Activity and Improve Healthy Eating in Early Childcare Centres	N/A
Completed	`NCT02074332` - Study on Obesity Intervention With Physical Exercise Among Students in Changping District, Beijing	N/A
Completed	`NCT02086851` - Study of a Structured Parent Intervention on Adolescent Weight Loss Modification Program.	N/A
Terminated	`NCT00846521` - Study of Post-meal Blood Sugar Peaks in Association With Vascular Disease in Childhood Obesity	Phase 4
Completed	`NCT01146314` - A Family Based Intervention to Reduce the Risk of Type 2 Diabetes in Children	N/A
Completed	`NCT04164277` - FirstStep2Health Intervention	N/A
Withdrawn	`NCT04600648` - Sweet Taste Responsiveness in Relation to Insulin, Leptin and Adiposity Among Obese Treatment Seeking Children	N/A
Completed	`NCT04395430` - A Novel School-clinic-community Online Model of Child Obesity Treatment in Singapore During COVID-19	N/A
Completed	`NCT03139877` - Pediatric Obesity Observational Prospective Trial

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Neuro-cognitive Impact of Juvenile Obesity — OBETEEN

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms