Patient Readmission Clinical Trial
Transition cAre inteRvention tarGeted to High-risk patiEnts To Reduce rEADmission (TARGET-READ)
|Source||University Hospital Inselspital, Berne|
|Contact||Jacques Donzé, MD, MSc|
|Start date||April 3, 2018|
|Completion date||December 31, 2019|
Hospital rehospitalizations within 30 days are frequent and represent a burden for the patients, but also for the entire health care system. This study evaluates the impact of an intervention targeted to high-risk medical patients in order to reduce their risk of rehospitalization. Half of the patients will receive a set of interventions before and after their hospital discharge, while the other half will receive usual care.
Background: Hospital readmissions within 30 days are frequent, with rates varying usually
between 12 and 20%. Is it therefore recognized as important to improve the quality of the
transition of care period in order to avoid as much as possible hospital readmissions. There
are however still several gaps in current knowledges. First, most trials to reduce hospital
readmission have been performed on specific patient populations such as patients with
diabetes or heart failure, and therefore the findings may not be well generalizable to other
high-risk population. Second, while some specific interventions have been showed to reduce
readmission, these were complex and resources demanding, and no trial targeted these
interventions to the patients who are most likely to benefit for better effectiveness, using
a widely validated prediction tool, such as the "HOSPITAL" score. Finally, most studies
tested unimodal interventions instead of more promising multimodal interventions.
Specific aim: the goal of this proposal is to evaluate the effect of a multimodal transitional care intervention prioritized to higher-risk medical patients on the composite of 30-day unplanned readmissions and death.
Methods: the investigators will conduct a multicenter randomized controlled trial in medical inpatients discharged home or nursing home, who are identified as having a higher risk for 30-day readmission. Risk of readmission will be predicted using the simplified HOSPITAL score, which includes 6 variables routinely available before hospital discharge and which has been previously validated in more than 200,000 patients across 6 countries in its original version, and in nearly 120,000 patients in its simplified version. Patients will be randomly assigned to the intervention group or usual care group. The primary outcome will be the first 30-day unplanned readmission or all-cause mortality. The primary analysis will be a comparison between two groups according to the intention-to-treat principle.
|Not yet recruiting||
|Not yet recruiting||