Patient Noncompliance Clinical Trial
Official title:
A Prospective Trial of Customized Adherence Enhancement Plus Long-acting Injectable Antipsychotic (CAE-L) in Individuals With Schizophrenia or Schizoaffective Disorder at Risk for Treatment Non-adherence and for Homelessness
Psychotropic medications are a cornerstone of treatment for individuals with schizophrenia
and schizoaffective disorder, however rates of full or partial non-adherence can exceed 60%.
Inadequate adherence is associated with poor outcomes such as relapse, homelessness,
hospitalization, and increased health care costs. Studies have shown a direct correlation
between non-adherence and rates of relapse in schizophrenia; on average, non-adherent
patients have a risk of relapse that is 3.7 times greater than their adherent counterparts.
A major obstacle to good outcomes in the maintenance treatment of patients with severe
mental illness is difficulty with medication routines on an on-going basis. For this reason,
long-acting injectable antipsychotic medication is a particularly attractive treatment
option for populations with schizophrenia and schizoaffective disorder, although it is
unlikely that medication treatment alone is likely to modify long-term attitudes and
behaviors.
This prospective study is a pilot analysis of a combined approach which merges a
psychosocial intervention to optimize treatment attitudes towards psychotropic medication
(CAE) and long-acting injectable antipsychotic medication (L) in recently homeless
individuals with schizophrenia or schizoaffective disorder who are known to have on-going
difficulties with treatment non-adherence. It is expected that this combined approach
(CAE-L) will improve illness outcomes among the most vulnerable of populations with
schizophrenia or schizoaffective disorder.
n/a
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Supportive Care
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT00694876 -
Impact of Health Literacy and Other Factors on Glaucoma Patient Adherence in South India
|
N/A |