Measurement and Modification of Threat Interpretation Bias in Neurodegenerative Movement Disorders (Aims 2 & 3)

Parkinson Disease Clinical Trial

Official title:

Measurement and Modification of Threat Interpretation Bias in Neurodegenerative Movement Disorders (Aims 2 & 3)

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05126862
• Other study ID #: HSR 210113
• Status: Completed
• Phase: N/A
• Start date: December 10, 2021
• Est. completion date: July 9, 2023

Study information

• Verified date: April 2024
• Source: University of Virginia
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is conduct a pilot open trial of a web-based cognitive bias modification intervention to reduce anxiety symptoms in persons with Huntington's disease and persons with Parkinson's disease.

Description:

After being informed about the study and giving informed consent, participants will enroll in a pilot open trial of MindTrails, a web-based cognitive bias modification intervention. Participants will complete five, 20-minute MindTrails training sessions over five weeks. Additionally, assessments of anxiety, interpretation bias, and other related outcomes will be completed at baseline, week 3, week 5, and 2 months following the last training session. Participants will each complete a semi-structured interview to provide qualitative feedback about their experiences with MindTrails and anxiety.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 43
• Est. completion date: July 9, 2023
• Est. primary completion date: July 9, 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 21 Years and older

Eligibility

Inclusion Criteria:

• Diagnosis of Huntington's disease or Parkinson's disease

• Age 21 or older

• Has anxiety symptoms (NeuroQoL Anxiety short form >12)

Exclusion Criteria:

• Unable to read and understand English

• Previously diagnosed with dementia

• Not located in the USA

Related Conditions & MeSH terms

• Huntington Disease
• Movement Disorders
• Parkinson Disease

Intervention

Behavioral:
• MindTrails
MindTrails is a web-based cognitive bias modification intervention. Training sessions are designed to encourage cognitive flexibility through repeated practice assigning benign resolutions to ambiguous, anxiety-provoking situations.

Locations

Country	Name	City	State
United States	University of Virginia	Charlottesville	Virginia

Sponsors (1)

Lead Sponsor	Collaborator
University of Virginia

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Proportion of participants completing at least 50% of the MindTrails sessions	Proportion of participants completing at least 50% of the MindTrails sessions	Between baseline and week 5
Primary	Participant perceptions of perceived benefits and limitations of MindTrails	Semi-structured interviews	After completion of the intervention (week 5)