Dual Frequency Stimulation in Parkinson's Disease

Parkinson Disease Clinical Trial

Official title: Dual Frequency, Dual Region Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson's Disease

Status Recruiting

Clinical Trial Summary

Deep brain stimulation (DBS) in the dorsal region of the subthalamic nucleus (STN) is very effective for reducing motor symptoms of Parkinson's disease (PD). Modeling studies suggest that this therapy may result in current spread into the ventral STN, causing altered cognitive processes. As a result, current stimulation parameters often lead to worsening in verbal fluency, executive function, and, particularly, cognitive control. There is evidence suggesting that low frequency oscillatory activity occurs across brain circuits important in integrating information for cognition. Preclinical studies and human recording studies indicate these low frequency theta oscillations drive cognitive control during cognitive tasks. Thus, the purpose of this study is to determine the safety, tolerability, and efficacy of low frequency stimulation (LFS) of the ventral STN alongside standard high frequency stimulation (HFS) of the dorsal STN in patients with PD.

Clinical Trial Description

n/a

Related Conditions & MeSH terms

• Parkinson Disease

• NCT number: NCT04650932
• Study type: Interventional
• Source: University of California, Davis
• Contact: Kiarash Shahlaie, MD, PhD
• Phone: 916-703-5505
• Email: krshahlaie@ucdavis.edu
• Status: Recruiting
• Phase: N/A
• Start date: October 22, 2022
• Completion date: December 2024