Parkinson Disease Clinical Trial
Official title:
Deep Brain Stimulation and Parkinson's Disease: Analysis of the Modifications of the Cortical Activation During Driving Tasks and During Tasks Involving the Control of the Impulses by Means of the Optical Imaging and of the Technique of Delay Discounting Task
- Background : Deep brain stimulation of SubThalamic Nucleus (STN-DBS) is an effective
treatment for a large variety of movement disorders. However, the efficacy of STN-DBS
relies on unclear mechanisms.
- Purpose: In this study, using optical imaging, the investigators will evaluate the
cortical hemodynamic changes induced by STN-DBS of parkinsonian patients during motor
task and delay discounting task. the investigators will perform an optical imaging study
using Near-InfraRed Spectroscopy (NIRS) in a parkinsonian patient after STN-DBS. The
investigators will measure bilateral local cortical hemodynamic changes under "On" and
"Off" stimulation conditions and during a motor task (left hand movement) and delay
discounting task Relative concentration changes of oxy-Hb, deoxy-Hb, and total Hb will
be continuously analyze.
- Primary outcome: Study of local cortical hemodynamic change (oxy-Hb, deoxy-Hb, and total
Hb) under " on " and " off " stimulation during a motor task.
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