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Clinical Trial Summary

This study will test the effectiveness (anti-tumor activity), safety, and ability to increase the body's immune system to fight pancreatic cancer by combining standard chemotherapy before and after surgery, with study drug PD-1 antibody, pembrolizumab, with and without study drug, focal adhesion kinase inhibitor (FAK), defactinib, in people with "high risk" resectable (surgically removable) pancreatic cancer. The purpose of this study is to evaluate if reprograming the tumor microenvironment by targeting FAK following chemotherapy can potentiate anti-programmed death-1 (PD-1) antibody.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT03727880
Study type Interventional
Source Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Contact Colleen Apostal, RN
Phone 410-614-3644
Email GIClinicaltrials@jhmi.edu
Status Recruiting
Phase Phase 2
Start date June 4, 2019
Completion date December 2024

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