Pancreatic Cancer Clinical Trial
Official title:
Atezolizumab Combined With BDB001 AnD Immunogenic Radiotherapy in Patients With Advanced Solid Tumors
Basket trial concept to independently and simultaneously assess the effects of the association of atezolizumab + BDB001 + radiotherapy in multiple solid tumors.
6 independent, multicenter, prospective, single-arm phase II trials, based on 2-stage Simon's optimal design, will be conducted in parallel to assess the efficacy of atezolimab + BDB001+ radiotherapy, separately, in distinct populations of solid tumors: - Population 1: pancreatic cancer - Population 2: virus-associated tumors - Population 3: anti-PD-1/L1 refractory non-small lung cancer - Population 4: soft-tissue sarcoma - Population 5: anti-PD-1/L1 refractory bladder cancer - Population 6: triple negative breast cancer ;
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