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Pancreatectomy clinical trials

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NCT ID: NCT06208579 Recruiting - Pancreatectomy Clinical Trials

Feasibility and Effectiveness of Augmented Reality Assistance System for Pancreatic Surgery

ARAS-P
Start date: September 11, 2023
Phase:
Study type: Observational

Pancreatic cancer necessitates surgical resection for complete tumor eradication, serving as the primary curative approach. However, pancreatic surgery is still challenging due to the organ's retroperitoneal anatomy and proximity to vital vascular systems. Thus, precise preparation and dissection of peripancreatic vessels are crucial during pancreatic surgery to reduce perioperative complications and improve oncological outcomes. The integration of preoperative computed tomography-derived reconstructed images, along with augmenting the resulting 3D model during surgical procedures, holds significant potential in this context. Augmented reality-assistance systems (ARAS) have seen use in various surgical fields, including orthopedic, plastic, and neurosurgery. Nevertheless, the application of ARAS in abdominal surgery has faced challenges related to organ shifting and deformities. The retroperitoneal nature of the pancreas, characterized by minimal intraoperative organ shifts and deformations, makes pancreatic surgery a promising candidate for ARAS. Despite this, there is a limited number of studies exploring the impact of ARAS during pancreatic surgery. Notably, existing investigations have primarily utilized augmented reality technology with 2D-display-based modalities. This prospective study aims to fill this gap by examining the usability, feasibility, and effectiveness of wearable ARAS during pancreatic surgery. By leveraging advanced technology seamlessly integrated into the surgical workflow, this research seeks to provide valuable insights into the practical application of ARAS, potentially enhancing the precision and outcomes of pancreatic surgery. The preliminary findings of this study will also be submitted for publication in a peer-reviewed journal.

NCT ID: NCT06126601 Recruiting - Pancreatitis, Acute Clinical Trials

Incidence and Clinical Impact of Serum Hyperamylasemia (POH) After Pancreatectomy on Postoperative Outcome and Patient Safety

HYPPO
Start date: July 18, 2023
Phase:
Study type: Observational

Recent evidence suggests that postoperative hyperamylasemia (POH) is a predictor of morbidity after pancreatectomy. This is based on the assumption that pancreatitis after pancreatectomy (PPAP) is a major trigger for the development of complications and is indicated by hyperamylasemia. Standardized prospective analysis and correlation with other laboratory parameters, hasn't been performed to date. Therefore the overall study aims are: - To prospectively evaluate the incidence and assess the clinical value of biochemical changes for the postoperative course. - To confirm and improve the definition and classification of postpancreatectomy acute pancreatitis (PPAP) of the International Study Group of Pancreatic Surgery (ISGPS) and to provide knowledge for effective early management of complications.

NCT ID: NCT05992857 Not yet recruiting - Clinical trials for Complication of Surgical Procedure

Pancreaticoduodenectomies With Complete Arterial Coverage by Retromesenteric Omentoplasty

PACOMARCO
Start date: February 2024
Phase: N/A
Study type: Interventional

To assess the efficacy of complete covering using retromesenteric omentoplasty vs. partial covering or no covering of peripancreatic arteries in decreasing incidence of grade B+C post-pancreatectomy hemorrhage (PPH), i.e. treated by transfusion and / or radiological or surgical hemostasis after PD in patients with high risk of POPF.

NCT ID: NCT05856474 Recruiting - Pancreatectomy Clinical Trials

Management of Traumatic Pancreas Transection

Start date: January 1, 2008
Phase:
Study type: Observational [Patient Registry]

The goal of this observational study is to learn about the type of surgical effect on pancreas transection. The main questions aims to answer are: - 1. does pancreas preserving able to decrease incidence of postoperative diabeters - 2. what is cause of major cause of postoperative morbidity and mortality in pancreas transection

NCT ID: NCT05737875 Not yet recruiting - Pancreatic Fistula Clinical Trials

Distal Pancreatectomy Pancreatic Fistula Risk Prediction Model Validation Study

DPFValid
Start date: March 1, 2023
Phase:
Study type: Observational

Distal pancreas resection is a relatively rare procedure with a known risk of postoperative pancreatic fistula. Until quite recently, no valid risk prediction models for this have been available. In 2022 two different risk scores DISPAIR and D-FRS were published. The aim of this study is to compare, validate and possibly improve those scores in a international retrospective multicenter cohort.

NCT ID: NCT05722548 Not yet recruiting - Pancreatectomy Clinical Trials

Efficacy of Rectal Indomethacin in Prevention of Post-pancreatectomy Acute Pancreatitis

Start date: February 1, 2023
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the efficacy of rectal indomethacin in prevention of post-pancreatectomy acute pancreatitis.

NCT ID: NCT05720338 Recruiting - Pancreas Neoplasm Clinical Trials

Is Intraperitoneal Drainage Necessary Following Distal Pancreatectomy?

Start date: April 13, 2023
Phase: Phase 3
Study type: Interventional

The goal of this clinical trial is to analyze if intraperitoneal drainage is necessary following distal pancreatectomy. This study aims to determine whether the omission of routine intraperitoneal drainage in the setting of reinforced staple technology is non-inferior to routine intraperitoneal drainage with respect to a composite post-operative complications of Grade B or C Postoperative pancreatic fistula (POPF), readmission, or organ space surgical site infection following a distal pancreatectomy.

NCT ID: NCT05297136 Recruiting - Pancreatic Fistula Clinical Trials

Preoperative Endoscopic Pancreatic Stent for Distal Pancreatectomy

Start date: March 21, 2022
Phase: N/A
Study type: Interventional

Distal pancreatectomy (DP) with or without splenectomy is commonly indicated for pancreatic body or tail lesions. Postoperative pancreatic fistula (POPF) remains the commonest complication after DP. A pre-operatively placed pancreatic stent across papilla can decrease the pressure gradient between pancreatic duct and duodenum. Therefore, the pancreatic juice flow is redirected from the pancreatic transection plane and leakage from pancreatic stump is much reduced. This study aims to evaluate whether pre-operatively placed pancreatic stent can prevent POPF by a randomized controlled trial.

NCT ID: NCT04850430 Not yet recruiting - Pancreas Cancer Clinical Trials

Gastric Venous Reconstruction After Total Pancreatectomy

GENDER
Start date: February 1, 2024
Phase: N/A
Study type: Interventional

Total pancreatoduodenectomy (TP) is the standard surgical approach for treatment of extended pancreas tumors. If the gastric coronary vein has to be sacrificed for oncologic or for technical reasons in total pancreatectomy with splenectomy, gastric venous congestion (GVC) may result because all major venous draining routes are terminated. In the sequelae of GVC, gastric venous infarction ultimately leads to gastric perforation with abdominal sepsis. To avoid gastric venous infarction, partial or even total gastrectomy is usually performed in the event of GVC after TP. However, this significantly impacts the patient's quality of life. Reconstruction of gastric venous outflow represents a technical approach to overcome GVC and to avoid gastric venous infarction making (partial) gastrectomy unnecessary. The current study aims to assess the role of gastric venous outflow reconstruction in GVC after TP to prevent (partial) gastrectomy.

NCT ID: NCT04431076 Active, not recruiting - Quality of Life Clinical Trials

Patient Reported Outcomes Measures to Predict Pancreatic Surgery Outcomes

PRO-PANC1
Start date: May 7, 2020
Phase:
Study type: Observational

This is a prospective single-center observational study with the mail objective to identify specific subgroups of patients planned for pancreatic resection, at high risk for postoperative morbidity and impaired recovery through preoperative screening of physical, functional, nutritional and psychological risk factors using patient reported questionnaires and performance tests. Consecutive patients planned for pancreatic resection will be enrolled to screen for physical, functional, nutritional and psychological risk factors. The study duration is 3 years: 2 years of recruitment and 1 year of follow-up. The findings of the present study will enable researchers to identify specific risk categories to plan personalized prehabilitation programs and modulate oncologic treatment strategies in cancer patients planned for pancreatic surgery.