Pain Clinical Trial
Official title:
A Double-Blind, Randomized, Split-Face Comparison Trial on Topical Anesthetic Agents Prior to Fractional Skin Resurfacing
The purpose of this research study is to test which topical anesthesia: LMX4 (Lidocaine 4%)
or BLT (Benzocaine 20%, Lidocaine 6%, and Tetracaine 4%) is more effective in reducing
discomfort during treatment with the Fraxel DUAL 1550/1927 (Solta Medical, Hayward, CA). No
studies have been done on the effectiveness of LMX4 versus BLT using the Fraxel DUAL,
although individually LMX4, BLT, and the Fraxel DUAL have been studied extensively.
The hypothesis is that there will be no clinical difference between the two topical
anesthetics.
Lasers can be effectively utilized for facial rejuvenation, reduction of photoinduced
rhytides, and dyschromia. Topical anesthetics are used to minimize the discomfort associated
with laser induced thermal pain. There are currently several formulations of topical
anesthesia. However, studies comparing the products are limited especially for the new
formulations that claim increased efficacy and faster onset.
LMX4 (Ferndale Laboratories, Ferndale, Michigan) is over the counter topical anesthesia. It
is 4% lidocaine that has been formulated into multilamellar vesicles containing several
lipid bilayers. This unique liposomal-based delivery system has been reported to deliver a
greater concentration of drug. This results in a longer duration of activity and faster
onset of action without requiring occlusion.4 Liposomes assist with drug penetration because
the skin is lipid bilayer that can encapsulate the drug.
BLT is a compounded topical anesthetic containing 20% benzocaine, 6% lidocaine, and 4%
tetracaine. It is commonly prescribed as topical anesthesia. All BLT products will be
compounded at the University Physicians Center Pharmacy to ensure safety and uniformity.
Anecdotally, some physicians claim it is the topical anesthesia of choice prior to laser
surgery.
The objective of the study is to evaluate the clinical efficacy of topical anesthetic
compounds prior to fractional skin resurfacing.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Active, not recruiting |
NCT05559255 -
Changes in Pain, Spasticity, and Quality of Life After Use of Counterstrain Treatment in Individuals With SCI
|
N/A | |
| Completed |
NCT04748367 -
Leveraging on Immersive Virtual Reality to Reduce Pain and Anxiety in Children During Immunization in Primary Care
|
N/A | |
| Terminated |
NCT04356352 -
Lidocaine, Esmolol, or Placebo to Relieve IV Propofol Pain
|
Phase 2/Phase 3 | |
| Completed |
NCT05057988 -
Virtual Empowered Relief for Chronic Pain
|
N/A | |
| Completed |
NCT04466111 -
Observational, Post Market Study in Treating Chronic Upper Extremity Limb Pain
|
||
| Recruiting |
NCT06206252 -
Can Medical Cannabis Affect Opioid Use?
|
||
| Completed |
NCT05868122 -
A Study to Evaluate a Fixed Combination of Acetaminophen/Naproxen Sodium in Acute Postoperative Pain Following Bunionectomy
|
Phase 3 | |
| Active, not recruiting |
NCT05006976 -
A Naturalistic Trial of Nudging Clinicians in the Norwegian Sickness Absence Clinic. The NSAC Nudge Study
|
N/A | |
| Completed |
NCT03273114 -
Cognitive Functional Therapy (CFT) Compared With Core Training Exercise and Manual Therapy (CORE-MT) in Patients With Chronic Low Back Pain
|
N/A | |
| Enrolling by invitation |
NCT06087432 -
Is PNF Application Effective on Temporomandibular Dysfunction
|
N/A | |
| Completed |
NCT05508594 -
Efficacy and Pharmacokinetic-Pharmacodynamic Relationship of Intranasally Administered Sufentanil, Ketamine, and CT001
|
Phase 2/Phase 3 | |
| Recruiting |
NCT03646955 -
Partial Breast Versus no Irradiation for Women With Early Breast Cancer
|
N/A | |
| Active, not recruiting |
NCT03472300 -
Prevalence of Self-disclosed Knee Trouble and Use of Treatments Among Elderly Individuals
|
||
| Completed |
NCT03678168 -
A Comparison Between Conventional Throat Packs and Pharyngeal Placement of Tampons in Rhinology Surgeries
|
N/A | |
| Completed |
NCT03931772 -
Online Automated Self-Hypnosis Program
|
N/A | |
| Completed |
NCT03286543 -
Electrical Stimulation for the Treatment of Pain Following Total Knee Arthroplasty Using the SPRINT Beta System
|
N/A | |
| Completed |
NCT02913027 -
Can We Improve the Comfort of Pelvic Exams?
|
N/A | |
| Terminated |
NCT02181387 -
Acetaminophen Use in Labor - Does Use of Acetaminophen Reduce Neuraxial Analgesic Drug Requirement During Labor?
|
Phase 4 | |
| Recruiting |
NCT06032559 -
Implementation and Effectiveness of Mindfulness Oriented Recovery Enhancement as an Adjunct to Methadone Treatment
|
Phase 3 | |
| Active, not recruiting |
NCT03613155 -
Assessment of Anxiety in Patients Treated by SMUR Toulouse and Receiving MEOPA as Part of Their Care
|