Investigating the Role of Brain-derived Neurotrophic Factor (BDNF) Between Pain and Other Neuronal Disease

Pain Clinical Trial

Official title:

Investigating the Role of Brain-derived Neurotrophic Factor (BDNF) Between Pain and Other Neuronal Disease

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03606915
• Other study ID #: B-ER-104-070
• Status: Completed
• Start date: July 10, 2015
• Est. completion date: December 31, 2019

Study information

• Verified date: February 2020
• Source: National Cheng-Kung University Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

Measure the cytokines, transforming or neurotrophic factors in CSF and plasma as the pain markers and as a new therapeutic target for pain control.

Description:

The research protocol was approved by the Institutional Review Board (IRB) for the Protection of Human Subjects at National Cheng Kung University Hospital (NCKUH/B-ER-104-070). The study procedures were performed according to the rules of IRB and fully explained to the participants. Blood and CSF samples were collected and compared the difference in no pain group, acute pain group, and chronic pain group.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 131
• Est. completion date: December 31, 2019
• Est. primary completion date: December 31, 2019
• Accepts healthy volunteers: No
• Gender: All
• Age group: 20 Years to 90 Years

Eligibility

Inclusion Criteria:

• . Patients undergo spinal anesthesia

• . Over 20 years of age

• Patients who are competent to understand the study and provide written informed consent.

Exclusion Criteria:

• Patients have the contraindication for spinal anesthesia (refuse spinal anesthesia, coagulopathy, severe aortic stenosis)

• Refuse participated in this study or pre-existent neurological disease.

• Patients with advanced tumor staging (stage 3 or 4).

Related Conditions & MeSH terms

• Pain

Intervention

Behavioral:
• pain evaluation
collect CSF during spinal anesthesia

Locations

Country	Name	City	State
Taiwan	National Cheng Kung University	Tainan

Sponsors (1)

Lead Sponsor	Collaborator
National Cheng-Kung University Hospital

Country where clinical trial is conducted

Taiwan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	cytokine measurement in cerebrospinal fluid	cytokine measurement ( via ELISA) in cerebrospinal fluid	through study completion, an average of 1 year
Primary	cytokine measurement in blood	cytokine measurement (via ELISA) in blood	through study completion, an average of 1 year