Clinical Trials Logo

Clinical Trial Summary

Pain is considered as one of the most important causal factors of behavioral and psychological symptoms in patients Alzheimer's disease and related disorders (ADRD). The investigators plan to examine the effectiveness of pain relief, pain sensory change (measured by quantitative sensory testing) and immune biomarkers change (measured by serum biomarkers) after the auricular point acupressure (APA). A waitlist and education control will be used to examine the feasibility of a 4-week APA intervention. The investigators will also explore potential analgesic pathways and underpinnings of APA on pain relief.

Clinical Trial Description

A waitlist and education control pilot study will be conducted to examine the feasibility of a 4-week APA intervention. This study will be conducted in two phases. In Phase 1, following the baseline assessment (1st home visit), participants will wait one month and will be randomized to an APA or education control group (to control time and attention). For the education control, each participant will be given 3 Alzheimer's Association publications (i.e., Basics of AD; Take Care of Yourself; and Behaviors). Both groups will have 1st office visit at pre-intervention, followed by three home visits weekly, 2nd office visit (post-intervention). After post-intervention assessment, the education control participants will cross over to the APA protocol. Participants at both groups will have three monthly follow-up (3 home visits) after the completion of APA. In Phase 2, all participants will be reassessed every three months for 6 months (2 follow-up phone surveys). ;

Study Design

Related Conditions & MeSH terms

NCT number NCT03393546
Study type Interventional
Source Johns Hopkins University
Status Not yet recruiting
Phase N/A
Start date February 1, 2018
Completion date December 30, 2018

See also
  Status Clinical Trial Phase
Not yet recruiting NCT03579446 - Levorphanol as A Second Line Opioid in Reducing Pain in Participants With Cancer Early Phase 1
Completed NCT01441141 - Genetics and Pain Severity in Sickle Cell Disease
Recruiting NCT03273114 - Cognitive Functional Therapy (CFT) Compared With Core Training Exercise and Manual Therapy (CORE-MT) in Patients With Chronic Low Back Pain N/A
Recruiting NCT03286543 - Electrical Stimulation for the Treatment of Pain Following Total Knee Arthroplasty Using the SPRINT Beta System N/A
Completed NCT02913027 - Can We Improve the Comfort of Pelvic Exams? N/A
Terminated NCT02181387 - Acetaminophen Use in Labor - Does Use of Acetaminophen Reduce Neuraxial Analgesic Drug Requirement During Labor? Phase 4
Completed NCT01077414 - Phenomenological Study of Psycho-Socio-Spiritual Healing in the Context of Chronic or Life-Threatening Illness
Completed NCT01198197 - PET Brain and Whole Body Distribution Studies for Nociceptin/Orphanin FQ Peptide (NOP) Receptor Using [11C]NOP-1A Early Phase 1
Enrolling by invitation NCT03272139 - Interscalene Block Versus Superior Trunk Block Phase 4
Completed NCT03459872 - Acupuncture Outcomes Based Rehabilitation N/A
Recruiting NCT03256487 - Intravenous Buprenorphine Versus Morphine for Severe Pain in the Emergency Department Phase 2
Recruiting NCT03170557 - Randomized Comparative Trial for Persistent Pain in Spinal Cord Injury: Acupuncture vs Aspecific Needle Skin Stimulation N/A
Completed NCT02533908 - Combination of Nitrous Oxide 70% With Fentanyl Intranasal for Procedural Analgosedation in Children Phase 3
Recruiting NCT02943772 - Does Local Cooling of Testis in Patients With Epididymitis Relieve Pain and Reduce Quantity of Analgetics Intake? N/A
Recruiting NCT02829736 - ThOracoscopic Wedge Resection Treated With Chest Tube Removal Intraoperatively N/A
Recruiting NCT02911168 - Comparison of US-Guided Paravertebral and Proximal Intercostal Nerve Blocks N/A
Active, not recruiting NCT02917603 - Shared Decision Making to Improve Palliative Care in the Nursing Home N/A
Not yet recruiting NCT02819544 - Evaluation of the Interest of the Instillation of Saline Intraperitoneally (INSI ) Versus Instillation of Naropin the Surgical Site Versus Lung Recruitment Maneuvers ( PVM ) in the Management of Pain After Laparoscopic Cholecystectomy in Ambulatory Care Phase 3
Not yet recruiting NCT02840942 - Robots to Reduce Pain During IV Placement N/A
Completed NCT02839889 - Tolerability, Safety, and Feasibility of Naloxegol in Patients With Cancer and OIC (Opioid Induced Constipation) Phase 4