Pain Clinical Trial
Official title:
Ketamine For Acute Treatment of Pain in Emergency Department
The aim of the study is to compare the safety & efficacy of low dose ketamine and morphine
versus morphine alone for acute generalized pain in the Emergency Department (ED). The
investigators are also interested to investigate whether low-dose ketamine is a safe and
effective alternative option to opioids for the acute treatment of pain in the Emergency
Department.
The agents that are available in the department includes acetaminophen, non-steroidal
anti-inflammatory (NSAIDS) and opioids. In most cases, acetaminophen and NSAIDS are not
adequate to manage acute pain crisis. There is also heightening concerns for increased
opioid use or abuse by patients. Since the HCAPHS survey includes various questions which
inquires about patient perception of pain management in the department, the investigators
are interested in investigating the safety and efficacy of low-dose ketamine to as an
alternative method to opioids for the acute management of pain. There has been limited,
mostly observational pilot studies, published in the literature. Limited data in the
literature have reported the incidence of nausea and vomiting ranged from 3-13%. All
published literature administered low-dose ketamine as an intravenous push. To the best of
our knowledge our study would be the first study to administer low-dose ketamine as a short
bolus infusion to mitigate the incidence of nausea and vomiting. The investigators believe
our study would provide important scientific data to fill the theoretical gap that low-dose
ketamine at 0.3mg/kg/dose may be a safe and effective agent for acute pain management in an
ED that is located in the center of a densely populated urban area.
The aim of the study is to compare the safety & efficacy of low dose ketamine and morphine versus morphine alone for acute generalized pain in the Emergency Department (ED). The is a randomized double blind placebo controlled trial to investigate the effects of low dose ketamine and morphine versus placebo and morphine for the management of acute pain in the ED. ;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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