Comparison Between Perineural and Systemic Effect of Dexamethasone as an Adjuvant for Prolongation of Four Nerve Blocks With Bupivacaine in Total Knee Arthroplasty

Pain, Postoperative Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02253784
• Other study ID #: 14-XX-HYMC
• Status: Completed
• Phase: N/A
• First received: September 29, 2014
• Last updated: October 30, 2017
• Start date: October 2014
• Est. completion date: October 30, 2017

Study information

• Verified date: October 2014
• Source: Hillel Yaffe Medical Center
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The addition of dexamethasone (DxaM) to local anesthetic may significantly prolong the duration of a block in total knee arthroplasty. The aim of this study is to determine whether this is a systemic or local effect.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 90
• Est. completion date: October 30, 2017
• Est. primary completion date: October 2016
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Pre-surgical total knee arthroplasty patients

Exclusion Criteria:

• Skin infection near block site

• Allergy to local anesthetics

• Peripheral neuropathy

• Proven opioid dependency

• Coagulopathy

• Dementia

Related Conditions & MeSH terms

• Analgesia
• Pain, Postoperative

Intervention

Drug:
• Dexamethasone

• Bupivacaine

Locations

Country	Name	City	State
Israel	Hillel Yaffe Medical Center	Hadera

Sponsors (1)

Lead Sponsor	Collaborator
Hillel Yaffe Medical Center

Country where clinical trial is conducted

Israel, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Efficacy Perineural DxaM	Duration of motor and sensory block	One day
Secondary	Efficacy of Systemic DxaM	Duration of motor and sensory block	One day