Pain, Postoperative Clinical Trial
Official title:
Cognitive Predictors of Persistent Post-surgical Pain (PPSP)
This observational study aims to determine the association between preoperative cognitive flexibility and the risk of developing PPSP by preoperative administration of cognitive tests.
Postoperative pain is a normal, physiologic, protective response to tissue injury that
routinely resolves after healing of the surgical site. However, in some patients, pain
persists long after surgery. PPSP is a diagnosis of exclusion that has most consistently been
defined as pain that (1) developed after a surgical procedure, (2) is not residual from a
preexisting condition, (3) has lasted for at least two months, and (4) is not attributable to
other causes. One suggested risk factor for PPSP is poorer performance on tests of cognitive
flexibility. Two common tests of cognitive flexibility are the Trail Making Tests (TMT) A and
B and the Color Word Matching Stroop Test (CWMST).
Three hundred patients undergoing either total knee arthroplasty or thoracotomy/mastectomy
will be enrolled. During preoperative evaluation, participants will complete the TMT and
CWMST. Subjects will be followed prospectively and will complete surveys at one month, six
months, and one year postoperatively to assess PPSP prevalence and intensity.
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