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Pain, Chronic clinical trials

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NCT ID: NCT06114264 Active, not recruiting - Low Back Pain Clinical Trials

Multimodal Intervention in Patients With Non-specific Chronic Low Back Pain: the HEALTHY BACK Project

Start date: January 1, 2023
Phase: N/A
Study type: Interventional

Low back pain is one of the most common health problems seen in the primary care. Chronic low back pain is localized between the inferior limit of the ribs and the sacral region, and persist more than 12 weeks. In most cases, it is attributed to a non-specific cause and classified as non-specific chronic low back pain (NSCLBP). No previous study has included a multimodal supervised program in patients with NSCLBP. The primary aim of this study is to determine the effectiveness of exercise + behaviour change + education + mindfulness programs (intervention 1) and an intervention including intervention 1 following functional resistance training (Intervention 2) on endogenous pain modulation, disability, muscle strength/endurance, quality of life, gait parameters, levels of physical activity, sedentary behaviour and psychological health in patients with NSCLBP.

NCT ID: NCT05659134 Active, not recruiting - Pain, Chronic Clinical Trials

Comparison of Alfredson and Silbernagel Protocol in Competitive Athletes With Achilles Tendinopathy

Start date: December 2, 2022
Phase: N/A
Study type: Interventional

A 6-week randomized clinical trial (RCT) with a 46-week follow-up compared the effect of Alfredson and Silbernagel eccentric programs for the treatment of AT. The primary outcome was a change in the Victorian Institute of Sport Assessment - Achilles (VISA-A) scale from baseline to 12 months. The study was approved by the Ethics Committee of the Faculty of Physical Education and Sport, Charles University (Project number: 254/2021). All participants provided written informed consent before participation.

NCT ID: NCT05562453 Active, not recruiting - Multiple Sclerosis Clinical Trials

Performance and Long-term Safety of FlowOx2.0™ in Patients With Multiple Sclerosis - Impact on Spasticity and Pain

FO-NP002
Start date: October 4, 2022
Phase: N/A
Study type: Interventional

The study is a 4-week double-blind, randomized, controlled, parallel design investigation to investigate the impact of intermittent negative pressure on spasticity and pain in people with multiple sclerosis (pwMS). The investigational device (FlowOx2.0™) is composed of a Pressure Chamber and a Control Unit (and disposable parts). All subjects will receive the same pressure chamber but be randomized to either a Control Unit that generates intermittent negative pressure (INP) of - (minus) 40 mmHg or a Control Unit that generates INP of - 10 mmHg. FlowOx2.0™ generating -40 mmHg is the investigational device, and FlowOx2.0™ generating -10 mmHg, is the comparator device. After the initial 4-week double-blind period, all participants will be offered the -40mmHg control unit to be used during a 6-months optional extension part.

NCT ID: NCT05122676 Active, not recruiting - Depression Clinical Trials

More Individualized Care: Assessment and Recovery Through Engagement

MI-CARE
Start date: November 10, 2021
Phase: N/A
Study type: Interventional

The MI-CARE trial tests 12 months of telephone-based nurse care management for patients with depressive symptoms who take or have taken opioids at some time. The study tests whether offering nurse support to the patient and their primary care team that addresses these things and related issues can improve patients' health and well-being. Eligible subjects are identified automatically using health system data and randomly assigned 50:50 to either a no-contact usual care arm or to the arm offered the MI-CARE program.

NCT ID: NCT04852484 Active, not recruiting - Pain, Postoperative Clinical Trials

Morphine Versus Ketamine as Adjuvants in Paravertebral Blocks

Annie-Dimitr
Start date: April 16, 2021
Phase: N/A
Study type: Interventional

The aim of this study will be to compare the effects of morphine versus ketamine when they are used as adjuvants to the local anesthetic in paravertebral nerve blocks performed with the aid of ultrasound. Furthermore, a group of local anesthetic without an adjuvant, will also be compared to the two groups

NCT ID: NCT04850079 Active, not recruiting - Pain, Acute Clinical Trials

EHR Precision Drug Treatment in Neonates

Start date: September 28, 2018
Phase:
Study type: Observational

This observational study is designed to evaluate the integration of a model-informed, clinically individualized pharmacokinetics (PK) profile (precision dosing dashboard) into prescribing clinicians' existing workflows to improve safety and efficacy of morphine dosing for neonates. The investigators will use user-centered participatory design methods and real-time analysis to inform the refinement of the recently developed Electronic Health Record (EHR) model-based decision support tool and test it during the pre-and post-implementation stages.

NCT ID: NCT04737746 Active, not recruiting - Pain, Chronic Clinical Trials

Caregiver Burden and Correlation With Clinical Outcome in Spinal Cord Stimulation for Chronic Neuropathic Pain

CAREstim
Start date: January 18, 2021
Phase:
Study type: Observational [Patient Registry]

Prospective multicentric observational trial on caregiver burden, caregiver satisfaction and clinical outcome in spinal cord stimulation for chronic neuropathic pain.

NCT ID: NCT04727216 Active, not recruiting - Pain, Chronic Clinical Trials

Intermittent vs. Continuous Dorsal Root Ganglion Stimulation

Start date: March 23, 2021
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate and compare the therapeutic efficacy of intermittent Dorsal Root Ganglion Stimulation (DRG-S) to standard continuous stimulation in patients with chronic intractable pain

NCT ID: NCT04624139 Active, not recruiting - Pain, Chronic Clinical Trials

Internet-based Cognitive Behavioral Therapy and Physiotherapy in Persons With Chronic Widespread Pain

Start date: November 4, 2020
Phase: N/A
Study type: Interventional

Objectives: To investigate the effect on pain of a stress reducing treatment that combine Internet based cognitive behavioral therapy (I-CBT) and physiotherapy in persons with chronic widespread pain (CWP) and to examine factors predicting potential improvement. Methods: 200 persons with CWP will be recruited from different parts of Region Västra Götaland (VGR) in Sweden, and randomized into two groups. Group 1: Combined intervention of stress reducing I-CBT and Physiotherapy. Group 2: Physiotherapy only. The participants complete a battery of questionnaires of symptoms and health related aspects at baseline, 6, 12 and 24 months. Interventions will take place at local rehabilitation centers in VGR.

NCT ID: NCT04523766 Active, not recruiting - Opioid Use Clinical Trials

Comparing the Impact of Mindful Interoceptive Mapping and Mindful Breathing on Pain and Opioid Use

Start date: June 29, 2021
Phase: N/A
Study type: Interventional

This is a single site, two-arm, parallel group randomized clinical trial comparing the effect of two mindfulness-based interventions (Mindful Interoceptive Mapping vs. Mindfulness of the Breath) on opioid-treated chronic pain patients' pleasant/unpleasant sensation reports and opioid use.