Ovarian Neoplasms Clinical Trial
Official title:
The BAROCCO Study (Best Approach in Recurrent-Ovarian-Cancer-with Cediranib-Olaparib): an Italian Multicenter Randomized Phase II Study of Weekly Paclitaxel vs. Cediranib-Olaparib With Continuous Schedule vs. Cediranib-Olaparib With Intermittent Schedule in Patients With Platinum Resistant High Grade Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer.
This is a Phase II, randomized, multi-centre study aiming at comparing the efficacy of
Olaparib and Cediranib vs. weekly Paclitaxel in terms of progression free survival (PFS) in
platinum refractory or resistant recurrent ovarian cancer.
Patients will be randomised in a 1:1:1 ratio to three treatment arms:
- Arm A: Paclitaxel 80 mg/mq every week
- Arm B: Cediranib 20 mg/day + Olaparib 600 mg / day (i.e. 300 mg BD) given every day
- Arm C: Cediranib 20 mg/day given 5 days per weeks + Olaparib 600 mg / day (i.e. 300 mg
BD) given 7 days per weeks
n/a
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