Ovarian Hyperstimulation Clinical Trial
Official title:
Progesterone Diurnal Rhythm During Ovarian Stimulation for IVF
To evaluate the influence of circadian rhythm on progesterone levels during follicular phase of natural cycle and during follicular phase of controlled ovarian stimulation during IVF.
The primary aim of this study is to determine the circadian rhythm of progesterone in a
stimulated cycle. Sample size calculations show that the study needs to recruit 10 women to
show any significant differences in progesterone secreted in the morning at 8 am compared to
that secreted in the evening at 8 pm. We have increased the number of participants to 12 in
order to compensate for any possible drop outs. The hormones FSH, LH, Progesterone and
Estradiol will be measured at days 2/3, 8, 10 and 12 of a normal and stimulated cycle so that
each patient serves as her own control.
This study will provide the basis to establish the optimal blood sampling time for
progesterone measurement and to more accurately determine the cut-off level for progesterone
for favourable pregnancy outcomes in ART.
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| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Active, not recruiting |
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N/A |