Myocardial Work for Prediction of Left Ventricular Remodeling in Patients With STEMI

ST-Segment Elevated Myocardial Infarction Clinical Trial

Official title:

Value of Myocardial Work for Prediction of Left Ventricular Remodeling in Patients With ST-Elevation Myocardial Infarction Treated by Primary Percutaneous Intervention

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05107102
• Other study ID #: STEMI-myocardial work
• Status: Completed
• Start date: September 10, 2019
• Est. completion date: August 30, 2021

Study information

• Verified date: October 2021
• Source: RenJi Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The study intends to investigate the alteration of regional myocardial work in patients with acute anterior myocardial infarction underwent primary percutaneous coronary intervention (PCI), and compare the distribution of regional myocardial work in patients with/without early remodeling at acute phase and 3-month follow-up.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 98
• Est. completion date: August 30, 2021
• Est. primary completion date: May 24, 2021
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 75 Years

Eligibility

Inclusion Criteria:

• Anterior myocardial infarct (anterior myocardial infarct is defined as persistent chest pain for 30 mins at least, with ST-segment elevation of at least 0.2 mV in two or more contiguous precordial leads) within 12 hours after onsets of symptom;

• Left anterior descending (LAD) as culprit vessel, with TIMI 0-1 grade.

Exclusion Criteria:

• significant valvular disease;

• cardiomyopathy; l

• left bundle branch block;

• atrial fibrillation;

• previous myocardial infarction (MI);

• history of cardiac surgery;

• pacemaker implantation.

Related Conditions & MeSH terms

• Infarction
• Myocardial Infarction
• ST-Segment Elevated Myocardial Infarction
• Ventricular Remodeling

Locations

Country	Name	City	State
China	Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University	Shanghai	Shanghai

Sponsors (1)

Lead Sponsor	Collaborator
RenJi Hospital

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Delta-work efficiency by echocardiography	A novel tool for non-invasive myocardial work(MW) assessment has been introduced to evaluate myocardial performance.MW was calculated as a function of time through a combination of LV global longitudinal strain(GLS) data and an estimated LV pressure curves. Work efficiency (WE) was calculated from the ratio of the constructive work to the sum of constructive and wasted work, expressed as a percentage.The values of culprit regional WE was expressed as WE-LAD.The values of non-culprit regional WE was expressed as WE-nonLAD.The absolute differences of the WE was calculated as the values of non-culprit regional WE minus the values of culprit regional WE, and noted as delta-WE.	24-72 hours after PCI
Secondary	Global work index by echocardiography	Global work index (GWI) is classified as total work within the area of the LV pressure-strain loop calculated from mitral valve closure to mitral valve opening.	24-72 hours, 3-month after PCI
Secondary	Global constructive work by echocardiography	Global constructive work (GCW) was defined as work contributing to LV ejection performed during shortening in systole and work performed during lengthening in isovolumic relaxation.	24-72 hours, 3-month after PCI
Secondary	Global work efficiency by echocardiography	Global work efficiency (GWE) was calculated from the ratio of the constructive work to the sum of constructive and wasted work, expressed as a percentage.	24-72 hours, 3-month after PCI
Secondary	Work index-LAD	Work index in left anterior descending(LAD) territory.	24-72 hours, 3-month after PCI
Secondary	Constructive work-LAD	constructive work in left anterior descending(LAD) territory.	24-72 hours, 3-month after PCI
Secondary	Work efficiency-LAD	Work efficiency in left anterior descending(LAD) territory.	24-72 hours, 3-month after PCI