| Eligibility |
Inclusion Criteria:
1. Histologically or cytologically proven metastatic or locally advanced HER2-positive
gastric cancer
2. Documented disease progression after receiving prior line of trastuzumab-containing
chemotherapy for gastric cancer
3. Able and willing to give written informed consent and has signed the informed consent
form (ICF), prior to performance of any trial activities.
4. Eligible male and female subjects aged =19 years.
5. Has measurable disease as determined by RECIST 1.1.
6. Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1.
7. Has baseline left ventricular ejection fraction (LVEF) = 55%.
8. Adequate organ function as demonstrated by laboratory test results within 14 days
prior to first dose of study treatment.
9. Have urinary protein that is <2 on dipstick or routine urinalysis.
10. Female subject of childbearing potential should have a negative urine or serum
pregnancy within 72 hours prior to first dose of study treatment.
11. Female subjects of childbearing potential and male subjects should be willing to use
methods of birth control for the course of the study and up to 120 days after the last
dose of study treatment.
Exclusion Criteria:
1. Received prior anticancer treatment with targeted agents, chemotherapy, or
radiotherapy within 14 days, with monoclonal antibodies within 28 days, has previously
received treatment with ramucirumab, or has participated in another clinical trial
within 14 days prior to start of study treatment.
2. Has experienced any Grade 3-4 gastrointestinal bleeding within 3 months prior to
treatment.
3. Has experienced any arterial thromboembolic events, including but not limited to
myocardial infarction, transient ischemic attack, cerebrovascular accident, or
unstable angina, within 3 months prior to treatment.
4. Has history of severe thromboembolism, including deep vein thrombosis and pulmonary
embolism within 6 months prior to treatment.
5. Has an active or ongoing infection, symptomatic congestive heart failure, uncontrolled
angina pectoris, symptomatic or poorly controlled arrhythmia, uncontrolled thrombotic
or hemorrhagic disorder, or any other serious uncontrolled medical disorders in the
opinion of the investigator.
6. Has ongoing or active psychiatric illness or social situation that would limit
compliance with study requirements.
7. Has known active central nervous system (CNS) metastases and/or carcinomatous
meningitis.
8. Has evidence of active, non-infectious pneumonitis.
9. Has a known history of Human Immunodeficiency Virus (HIV).
10. Has known active hepatitis B or hepatitis C.
11. Have an elective or a planned major surgery during the course of the trial or has
undergone major surgery within 4 weeks prior to enrollment.
12. Has history of GI perforation and/or fistula within 6 months prior to treatment.
13. Is pregnant or breastfeeding, or possibly pregnant.
14. Has history of Child-Pugh Class B or more of liver cirrhosis or hepatic
encephalopathy, or cirrhosis with clinically meaningful ascites.
15. Is undergoing long-term antiplatelet therapy within 7 days prior to treatment.
16. Has known history of hypersensitivity to one or more of the study treatments or their
substances, or known severe hypersensitivity to monoclonal antibodies.
17. Has a known additional malignancy that is progressing or has required active treatment
within the past 3 years.
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