Osteopathic Manipulative Treatment Induces Functional Connectivity Changes

Osteopathic Manipulative Treatment Clinical Trial

Official title: Osteopathic Manipulative Treatment Induces Functional Connectivity Changes: a Randomized Manual Placebo-controlled Trial

Status Completed

Clinical Trial Summary

Osteopathic Manipulative Treatment (OMT) is a whole-body intervention mainly focused on correcting the somatic dysfunctions present in different regions of the body. Osteopathic research to date has mostly been concerned with various clinical conditions such as musculoskeletal disorders and primary headache. The neurophysiological effects underlying clinical improvements are still under debate. Although models explaining the therapeutic effects of OMT include the potential for higher brain mechanism, OMT effects on functional brain connectivity is not fully understood and still lacking in healthy adults. Magnetic resonance imaging (MRI) research includes several different approaches to estimate cortical functions. Several of these approaches have demonstrated functional brain changes associated with OMT. Using Arterial Spin Labeling MRI, recently was demonstrated that the treatment of somatic dysfunctions induces cerebral perfusion changes in asymptomatic young participant. Thus, the aim of this study is to explore the neural correlates associated with OMT effect in terms of cerebral functional connectivity, as derived by complex network analysis of resting state fMRI data recorded in asymptomatic young volunteers with somatic dysfunctions

Clinical Trial Description

n/a

Related Conditions & MeSH terms

• Osteopathic Manipulative Treatment

• NCT number: NCT04387006
• Study type: Interventional
• Source: I.R.C.C.S. Fondazione Santa Lucia
• Status: Completed
• Phase: N/A
• Start date: September 30, 2017
• Completion date: January 8, 2019