Un-ruptured Intracranial Aneurysm,Interventional Therapy,Craniotomy Clinical Trial
Official title:
Prospective Cohort Study of Interventional Therapy and Craniotomy for Unruptured Aneurysms
Un-ruptured intracranial aneurysm is a complex disease that seriously affects human life and
health. At present, the treatment of intracranial aneurysm is divided into interventional
treatment and craniotomy clipping, the two treatment methods are different in the
intervention effect of aneurysm, for example, the complications of interventional therapy
are lower than craniotomy clipping, but the long-term patency rate is lower than craniotomy
clipping, and there is no standard of treatment in different parts of aneurysm in our
country, the choice of intervention measures of un-ruptured aneurysm is different in
different clinical centers; on the other hand, there are serious problems in the treatment
of aneurysms, because without the relevant guidelines of diagnosis and treatment of
intracranial aneurysms, different clinical centers will cause excessive treatment of
un-ruptured aneurysms, not only bring unreasonable utilization of medical resources, but
also cause the subject's life and property to be threatened.
The patients with un-ruptured intracranial aneurysm(n=1500) were included in prospective
cohort study, after clipping and intervention operation, setting fixed time for
postoperative follow-up, the clinical data and image data were recorded, the safety,
efficacy and economic benefits of interventional treatment and craniotomy clipping were
compared, providing strategies for the standardized treatment of un-ruptured intracranial
aneurysms.
For this study,investigators consulted and hired professionals and experts about data collection, data and methodology,including Data Monitoring Committee, Data Management Committee, Progect Academic Committee, Executive Group, Project Manager, Project Statistician,Technical Support Center. investigators have a scientific regulations for this project. Project Manager and Executive Group: To ensure the successfully implementation of this project, including charging the daily operations of the study in 20 different research hospitals, organizing the monthly meeting to consider issures raised during the monthly progress of the study, liaising with the steering committee,the data management centre and statistical centre. Data management Committee: To be responsible for setting up and maintain the Electronic Data Capture (EDC) System according to the papera Case Report Form(pCRF) designed by principal investigators. To collect and save the pCRF coming from sub-centers. To entry the data into EDC system and keep the same with CRF. To organize training for the investigators about the rules in filling the EDC and pCRF.To determine the frequency of the Data Management Report and to fed it back to the steering committee every three months. Data Mornitoring Committee: To determine the frequency of the data mornitoring including the source data(Medical records) accuracy, completeness and representativeness comparing the external data(EDC, pCRF) in 12 centers. To report the results after the mornitoring back to the steering committee about the missing data, non-reported and other problems about the study. To make a Standard Operation Procedure(SOP) from getting data to using data. Academic Committee: To supervise the academic issues including patient recruitment, protocol deviation, adverse events evalutating. To settle down the question and problem in the process of the study. Project Statistician: We cooperate with the statisticians of Medical Research & Biometrics Center National Center for Cardiovascular Diseases, China to get the perfessional statistical report. Technical Support Center:To provide technical support during the process of the study. ;