Hypertrophic Obstructive Cardiomyopathy Clinical Trial
Hypertrophic Obstructive Cardiomyopathy (HOCM) patients have significant clinical symptoms,
including progressively increasing fatigue, angina, exertional dyspnea, and syncope.
Conservative medications are used to treat the vast majority of patients. Invasive therapy,
which includes surgical myectomy, septal ethanol ablation and dual-chamber pacing is
introduced to patients with refractory symptoms or drug resistance. Considering the
sternotomy and relatively high patients' tolerance required in myectomy, the potentially
risky misplacement of ethanol and the anatomic variability of the vascularised hypertrophic
septum, and the potential risk of conduction block after these two treatments, the
development of new minimally invasive approach is warranted.
Previous researches have illustrated the effectiveness and feasibility of transcatheter
radio frequency ablation for HOCM patients. By far, there has been no report on
transthoracic laser-induced interstitial thermotherapy (LITT) for human treatment. Since
2004, our department has adopted High Intensity Focused Ultrasound, radio frequency and
laser in solid tumors treatment, including liver tumors and fibroid. Also our center has
conducted several animal experiments to verify the feasibility of radio frequency/laser in
septal myocardium ablation.
The purpose of this study is to lead echocardiography-guided transthoracic radio
frequency/laser ablation for HOCM ventricular septum, make minimally invasive treatment
plans for HOCM patients, and verify the safety and validity of intervention treatment in
long term.
n/a
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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