Surgical Extraction of Impacted Third Molars Clinical Trial
Official title:
The Effect of Topical Application of Manuka Honey on Healing After Extraction of Impacted Lower Third Molars: A Split-Mouth Design Randomized Controlled Trial
Since there is an evidence that Manuka honey is an antibacterial agent, the present study aims to confirm this characteristic and assess its effect in improving healing and reducing postsurgical symptoms, if topically applied after the surgical removal of impacted mandibular third molars
Sufficient evidence exists recommending the use of honey in the management of acute wounds
and burns. Studies revealed that the healing effect of honey could be classified by its
antibacterial, antiviral, anti-inflammatory and antioxidant properties of its components.
Manuka honey has been shown to inhibit a wide range of microorganisms, including
multiresistant strains. This unique honey is derived from flowers of manuka tree
(Leptospermum scoparium) in New Zealand. Dihydroxyacetone and methylglyoxal are unique and
naturally occurring constituents of manuka honey that correlate with its antibacterial
activity.
Since surgical extraction of impacted molars is one of the most common operations in the
oral cavity and the postoperative symptoms disturbing the patient may reduce the quality of
health service, this study aims to assess the healing potential of Manuka honey in reducing
these symptoms by comparing the outcome of extraction of impacted lower molars with and
without topical application of Manuka honey into the extraction socket.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment