Penile Squamous Cell Carcinoma Stage IV Clinical Trial
— PAZOPEN-SOGUGOfficial title:
Phase II Study With Pazopanib and Weekly Paclitaxel in Metastatic or Locally Advanced Squamous Penile Carcinoma Patients Previously Treated With Cisplatin Based Chemotherapy
Penile cancer is an uncommon disease, with devastating physical and psychological effects on
patients. Penile carcinoma even in advanced stages is responsive to several chemotherapeutic
agents. However, due to the low incidence of penile cancer, no large studies have been
reported concerning chemotherapy.
Various single agents were tested for activity en penile cancer in de 70s and 80s. Response
rates ranged from 10 to 27% with cisplatin, 20 to 21% with bleomycin, and 0-62% with
methotrexate. These agents in combination were tested in different studies. Other
chemotherapy schemes have been studied, as combination of cisplatin with 5 fluorouracil with
or without taxol, and cisplatin plus irinotecan. All of them in limited phase II studies,
with described higher responses rates in some of them but without results confirmation in
phase III studies.
In conclusion, tested regimens so far have not been very successful in advanced stages of
the disease.
Antiangiogenic therapy has been demonstrated effective in the treatment of similar cancer
types as lung and head and neck, so it can be postulated that antiangiogenic therapy can be
effective in the treatment of penile carcinoma. Pazopanib is a new potent oral
antiangiogenic therapy.
Cytotoxic agents, such as paclitaxel, when administered at low doses and frequent intervals,
may exert antiangiogenic effects, thereby enhancing anticancer activity. Recently,
combination of pazopanib and paclitaxel administered in a metronomic schedule (80mg/m2
weekly 3 weeks every 4 weeks cycle) obtained a 40% response rate and an 80% of disease
control in the first-line treatment of melanoma patients. Treatment was well tolerated.
As paclitaxel and antiangiogenic drugs seem a very active treatment, combination of
pazopanib and paclitaxel seems a good combination to be tested in patients with penile
carcinoma.
| Status | Terminated |
| Enrollment | 4 |
| Est. completion date | September 2016 |
| Est. primary completion date | September 2016 |
| Accepts healthy volunteers | No |
| Gender | Male |
| Age group | 18 Years and older |
| Eligibility |
Inclusion Criteria: - Written informed consent - Age >= 18 years - Histologically confirmed diagnosis of squamous cell carcinoma of the penis - Eastern Cooperative Oncology Group (ECOG) performance status of 0-1. - Measurable disease criteria according to RECIST criteria (version 1.1) - Progressive disease after treatment with cisplatin or carboplatin based chemotherapy. - Archived tumor tissue must be provided for all subjects for biomarker analysis before and/or during treatment with investigational product. - Adequate organ system function - Haemoglobin >= 9.0 gr/dl (5.6 mmol/L) and stable in the previous 4 weeks to start study treatment - Neutrophils >= 1.5 x 10*9/L - Platelets >= 100 x 10*9/L - Total bilirubin <= 1.5 x UNL - AST/SGOT and ALT/SGPT <= 2.5 x UNL - serum creatinine <= 1.5 mg/dL - Urine protein to creatinine ratio < 1. - Normal coagulation tests: - Prothrombin time (PT) or international normalized ratio (INR) <= 1.2 X ULN - Activated partial thromboplastin time (aPTT) <= 1.2 X ULN 10. Are able to swallow and retain oral tablets Exclusion Criteria: - Prior malignancy. - Central nervous system metastases at baseline, with the exception of those subjects who have previously-treated CNS metastases (surgery ± radiotherapy, radiosurgery, or gamma knife) and who meet both of the following criteria: a) are asymptomatic and b) have no requirement for steroids or enzyme-inducing anticonvulsants - Clinically significant gastrointestinal abnormalities that may increase the risk for gastrointestinal bleeding. - Clinically significant gastrointestinal abnormalities that may affect absorption of investigational product. - Corrected QT interval (QTc) > 480 ms - History of any one or more of the following cardiovascular conditions within the past 6 months: - Cardiac angioplasty or stenting - Myocardial infarction - Unstable angina - Coronary artery bypass graft surgery - Symptomatic peripheral vascular disease - Class III or IV congestive heart failure, as defined by the New York Heart Association (NYHA) - Poorly controlled hypertension [defined as systolic blood pressure (SBP) of >= 140 mmHg or diastolic blood pressure (DBP) of >= 90 mmHg]. - History of cerebrovascular accident including transient ischemic attack (TIA), pulmonary embolism or untreated deep venous thrombosis (DVT) within the past 6 months. - Evidence of active bleeding or bleeding diathesis. - Known endobronchial lesions and/or lesions infiltrating major pulmonary vessels that increase the risk of pulmonary hemorrhage - Recent hemoptysis (>= 1/2 teaspoon [2.5 mL]) of red blood within 8 weeks before first dose of study drug). - Any serious and/or unstable pre-existing medical, psychiatric, or other condition that could interfere with subjects safety, provision of informed consent, or compliance to study procedures. - Unable or unwilling to discontinue use of prohibited medications 14 days prior to the first dose of study drug and for the duration of the study. - Treatment with any of the following anti-cancer therapies: - radiation therapy, surgery or tumor embolization within 14 days prior to the first dose of pazopanib OR - chemotherapy, immunotherapy, biologic therapy, investigational therapy or hormonal therapy within 14 days prior to the first dose of Pazopanib - Administration of any non-oncologic investigational drug within 30 days prior to receiving the first dose of study treatment - Any ongoing toxicity from prior anti-cancer therapy that is >Grade 1 and/or that is progressing in severity, except alopecia. - Have a known immediate or delayed hypersensitivity reaction or idiosyncrasy to drugs chemically related to pazopanib or paclitaxel and/or excipients that contraindicates their participation. - Previous taxane or/and antiVEGF treatment would not allow patient to participate in the study. |
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
| Country | Name | City | State |
|---|---|---|---|
| Spain | Hospital de La Santa Creu I Sant Pau | Barcelona | |
| Spain | Complejo Hospitalario Regional Reina Sofía | Córdoba | |
| Spain | Institut Català D'Oncologia L'Hospitalet | Hospitalet de Llobregat | Barcelona |
| Spain | Hospital Universitario Lucus Augusti | Lugo | |
| Spain | Hospital Clínico San Carlos | Madrid | |
| Spain | Hospital General Universitario J.M. Morales Meseguer | Murcia | |
| Spain | Complejo Hospitalario de Navarra | Pamplona | Navarra |
| Spain | Instituto Valenciano de Oncología | Valencia |
| Lead Sponsor | Collaborator |
|---|---|
| Spanish Oncology Genito-Urinary Group |
Spain,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Overall response rate | Evaluate response rate in terms of complete and partial response (RECIST criteria version 1.1) | Up to 6 months | No |
| Secondary | Clinical benefit rate | Clinical benefit rate (complete and partial response and stable disease) evaluated according RECIST criteria version 1.1 | Up to 6 months | No |
| Secondary | Progression free survival | Time from patient inclusion until progression disease (RECIST criteria version 1.1) or death from any cause, whichever came first, assessed up to 12 months | Up to 12 months | No |
| Secondary | Response duration | Time from first response to progression disease (RECIST criteria version 1.1) or death from any cause, whichever came first, assessed up to 12 months | Up to 12 months | No |
| Secondary | Overall survival | Time from patient inclusion to death assessed up to 18 months | Up to 18 months | No |
| Secondary | Safety tolerability profile as measured by the number of events per patient | Number of events per patient | Up to 6 months | Yes |