Clinical Trials Logo

Clinical Trial Summary

Left ventricular diastolic dysfunction is caused by impaired relaxation and increased left ventricular stiffness with a consequent increase in filling pressures. Currently, it is possible to classify it in 3 grades: grade 1 with normal filling pressures, grade 2 and grade 3 with high pressures. Diastolic dysfunction is closely associated with several risk factors such as hypertension, diabetes, and obesity, as well as the risk of heart failure, cardiovascular events, and death. In the field of cerebrovascular diseases, however, diastolic dysfunction is still being researched. Thus, this study aims to: 1) evaluate the white matter hyperintensities volume in association with the increase of diastolic dysfunction and filling pressures 2) evaluate the possible association with carotid atherosclerosis in case of brain damage caused by dysfunction diastolic 3) understand the mechanism of damage caused by left ventricular diastolic dysfunction on the cerebrovascular system. In order to do this, this study proposes to evaluate in a cohort of patients, between 35 and 65 years, the possible association of diastolic dysfunction with lesions on the cerebrovascular system in a future view of new marker of brain damage and new modifiable risk factor.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04549298
Study type Observational
Source Neuromed IRCCS
Contact Giuseppe Lembo, MD, PhD
Phone +390865915225
Email lembo@neuromed.it
Status Not yet recruiting
Phase
Start date October 2022
Completion date October 2023

See also
  Status Clinical Trial Phase
Terminated NCT01888796 - Diastolic Dysfunction in Patients With Type 2 Diabetes Mellitus Phase 3
Active, not recruiting NCT03962166 - Characterizing Patients With POAF in Relation to Cardiac Surgery by wavECG and TTE
Completed NCT04154878 - 2 New Measurements Used to Describe the Filling Phase of the Left Ventricle (LV).
Recruiting NCT01747187 - Cardiac Stress in Septic Shock - Biomarkers, Echocardiography and Outcome N/A
Completed NCT02251431 - Extended Release Exenatide Versus Placebo In Diabetic Patients With Type 4 Cardiorenal Syndrome Phase 3
Completed NCT04699565 - Characterization of Patients With Post-ischemic Left Ventricular Dysfunction
Recruiting NCT04752293 - Pediatric Hypertension and the Renin-Angiotensin SystEm (PHRASE)
Completed NCT01961323 - Effect of Nebivolol on the Blood Flow in Hearts of Adults With High Blood Pressure and Abnormal Filling of Heart Phase 4
Completed NCT00405548 - Human Brain Natriuretic Peptide (BNP) (or Nesiritide) to Help Heart, Kidney and Humoral Function. Phase 1/Phase 2
Recruiting NCT04433533 - Compare the Efficacy and Safety of Rosuvastatin/Ezetimibe Combination Therapy Versus Rosuvastatin Monotherapy in Korean Patients With Left Ventricular Diastolic Dysfunction and Hyperlipidemia Phase 4
Recruiting NCT03534037 - Urate Lowering Therapies and Left Ventricular Diastolic Dysfunction Phase 4
Active, not recruiting NCT04687111 - Personalised Prospective Comparison of ARni With ArB in Patients With Natriuretic Peptide eLEvation Phase 2
Completed NCT04505449 - Invasive Left Heart Catheterization Registry
Completed NCT04703387 - Left Ventricular Diastolic Dysfunction as a Predictor of Weaning Failure From Mechanical Ventilation
Terminated NCT03495999 - Hyperuricemia and Left Ventricular Diastolic Function
Completed NCT03522194 - Left Ventricular Diastolic Function During Anesthesia Induction