Oral Lichen Planus Related Stress Clinical Trial
Official title:
Assessment of Anxiety and Depression in Symptomatic Oral Lichen Planus
Oral lichen planus (OLP) is a T-cell mediated chronic immunological disease directed to a
still unknown antigen. It is a mucocutaneous and a psychosomatic disorder, with unknown
prevalence rate; however studies suggest an incidence of 0.02 to 0.22% among the Indian
population. 75% of patients with cutaneous lichen planus also experience oral lesions and may
be precipitated or exacerbated by psychosocial stressors.
In conditions like pain, anxiety and stress, many metabolic and endocrine changes occur in
the body, the most common effect of which is increased cortisol level in blood. This hormone
is a 21-carbon corticosteroid secreted by adrenal cortex and regulates the metabolism of
carbohydrates, fats, proteins and water. Also known as stress hormone, cortisol is a decisive
index in stressful situations.
This study is intended to correlate the serum cortisol levels with anxiety and depression in
patients with symptomatic oral lichen planus. This study attempts to evaluate psychological
anxiety and depression in oral lichen planus subjects using Hospital Anxiety and Depression
Scale ( HADS) and correlating with their serum cortisol levels.
To understand and explore the etiopathogenesis for better management of oral lichen planus.
Oral lichen planus (OLP) is a T-cell mediated chronic immunological disease directed to a
still unknown antigen. It is a mucocutaneous and a psychosomatic disorder, with unknown
prevalence rate; however studies suggest an incidence of 0.02 to 0.22% among the Indian
population. 75% of patients with cutaneous lichen planus also experience oral lesions and may
be precipitated or exacerbated by psychosocial stressors.
In conditions like pain, anxiety and stress, many metabolic and endocrine changes occur in
the body, the most common effect of which is increased cortisol level in blood. This hormone
is a 21-carbon corticosteroid secreted by adrenal cortex and regulates the metabolism of
carbohydrates, fats, proteins and water. Also known as stress hormone, cortisol is a decisive
index in stressful situations.
This study is intended to correlate the serum cortisol levels with anxiety and depression in
patients with symptomatic oral lichen planus.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT06332365 -
Evaluating Treatment Efficacy in Oral Lichen Planus: The Role of Salivary Biomarkers
|
N/A |