Diabetes Mellitus With Periodontal Disease Clinical Trial
Official title:
The Effects of Non-surgical Periodontal Therapy Plus Doxycycline on HbA1c in Patients With Type 2 Diabetes Mellitus: A Randomized Clinical Trials
Aim:
The purpose of this study is to investigate the effect of nonsurgical periodontal therapy
plus doxycycline on glycemic control in type 2 diabetes mellitus (type 2 DM) patients who
have periodontitis.
Materials and methods:
A total of 24 type 2 DM patients with periodontitis will be selected for the study, and
randomly divided into two equal groups,who are at least 35 years of age and 16 teeth and
type II diabetes are (at least the last 3 months of diagnosis of diabetes and its FBS More
than 110 have), and also with periodontal disease are chronic moderate (at least in three
areas Attachment level to a depth of 3-4 mm maxillary or mandibular been confirmed by
clinical examination and radiographic signs are being); Takes place. The initial HbA1c
Patients should be between 7-9 percent over the past three months has changed his medication
also found the necessary explanations on how to do that consent, Plaque index (PI) by Loe &
Silness, bleeding on probing (BOP) based on Carter and Barnes (if any bleeding number 1 and
its absence is 0), probing depth (PD) and clinical attachment levels (CAL) were recorded.
"Group 1": (12 patients) was treated with oral hygiene instruction, Scaling, and root
planing, and doxycycline for 15 days; and "Group 2": (12 patients) has the same treatment
but with placebo, After 12 weeks their periodontal condition and Fasting blood sugar (FBS),
glycated hemoglobin (HbA1c) level, will be reevaluated.
Doxycycline downregulates the activity of matrix metalloproteinases (MMPs), key destructive enzymes in periodontal disease ;
Allocation: Randomized, Endpoint Classification: Safety Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT04865809 -
Use of Ozonized Water With Toothpaste and Mousse in Non Surgical Periodontal Therapy for Patients With Diabetes Mellitus Type 1: a Randomized Clinical Trial.
|
N/A | |
| Completed |
NCT02735837 -
The Effect of Topical Doxycycline Gel on HbA1c in Patients With Type 2 Diabetes Mellitus(DM) ®
|
Phase 2/Phase 3 |