Renal Failure Chronic Requiring Dialysis Clinical Trial
Official title:
Assessment the Dosage of Troponin T Hypersensitive Dosage in a Patient Population Hemodialysis and Peritoneal Dialysis (ECHOTnT)
"Troponin T (TnT) is a component of the contractile apparatus of the striated musculature.
Although the function of TnT is the same in all striated muscles found in the heart to form
a TNT (cardiac TnT) differing significantly TnT of the skeletal muscles. Because of its high
tissue specificity, cardiac TnT is a specific marker and highly sensitive of myocardial
injury.
Asymptomatic elevations of troponins is frequently found in patients with chronic renal
failure in stage V, which present no clinical signs of acute or electrical myocardial
injury.
Many studies have been conducted in recent years to explain the origin and clinical
significance of this elevation, but the results are controversial: cardiac dysfunction, left
ventricular hypertrophy or chronic inflammation.
Besides the effect of the dialysis session was evaluated on this biological parameter in
different studies which together do not find Impact hemodialysis session on the value of
troponin Achieving dosages rate hypersensitive serum troponin T in a dialysis population,
will:
- to determine the evolution of TnT in time and what are the characteristics of the
patients for whom this rate varies
- to know what its evolution during the session,
- to identify if possible the criteria that are responsible for the variation in the
direction of increasing and / or its reduction
- and to characterize patients whose base rate is higher than the 99 percentile in the
absence of clinical symptoms which could lead to establish reference population for
this specific normal values. The Purpose of this study is to evaluate the serum
troponin T in a hypersensitive dialysis population and verify what is the influence of
the hemodialysis session, the session parameters and intradialytic events on changes in
serum troponin T hypersensitive after a hemodialysis session. "
Current care study, single-center, uncontrolled, no randomised, open and prospective.
Two hundred fifty patients on hemodialysis and / or peritoneal dialysis for more than 3
months may be included in the study for a total period of 7 months.
Hemodialysis patients will be informed at the weekly routine visits. Regarding peritoneal
dialysis patients, a meeting can be organized with the physician. And the oral agreement of
the patient will be collected during a second visit or meeting.
The protocol provides four follow-up visits: at baseline, 4 weeks, 12 and 24 weeks.
During these visits, the patient will have a clinical examination and a measure of the serum
troponin T. Blood samples are realized in the usual conditions of the center - for
hemodialysis patients: midweek as instructed by the usual protocol of the center. - for
peritoneal dialysis patients: when the monthly routine consultation.
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