Clinical Trials Logo
  1. Home
  2. Other
  3. NCT02034396

Clinical Implications of Genetic Variations of Venous Stasis Ulceration

Venous Ulcers Clinical Trial

Official title:
Clinical Implications of Genetic Variations of Venous Stasis Ulceration

Clinical Trial Summary

Currently, there is no standard approach for the treatment of patients with venous stasis ulcers, and no means of accounting for the genetic factors that may contribute to a patient's response to different therapeutic interventions. In order to determine whether, or to what extent, genetic profiling of venous stasis ulcers can stratify patients according to their potential for disease progression or healing, and guide preventive strategies and levels of therapeutic interventions, the study will involve retrospective genetic profiling of patients with a healed or persistent venous stasis ulcer as a means of determining the efficacy of current therapies, and to establish a future prospective evaluation of treatment algorithms based on genetic phenotype and variation. Results obtained from the 2 aforementioned groups of participants will be compared with those of a control group of participants who have no history of venous ulcer nor peripheral vascular disease. .

Clinical Trial Description

A blood specimen will be drawn, medical and medication history taken, and wound/s will be assessed and followed for 2 years in regard to the enrollees w/active venous ulcer/s or healed venous ulcer/s. A venous duplex ultrasound of right and left lower extremities will be done at no cost, a blood specimen will be drawn, and medical and medication history will be taken in regard to control group enrollees. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02034396
Study type Interventional
Source University of Pittsburgh
Contact
Status Completed
Phase N/A
Start date May 2011
Completion date March 31, 2022
View Details
See also
  Status Clinical Trial Phase
Completed NCT00207818 - Treatment of Cutaneous Ulcers With a Novel Biological Dressing Phase 1/Phase 2
Terminated NCT00545298 - Safety and Efficacy of Gaseous Nitric Oxide on Venous Stasis Leg Ulcers Phase 2
Completed NCT03070925 - Prospective PuraPly™ AM Case Series Study N/A
Not yet recruiting NCT01491438 - Plasma Rich Growth Factors in Venous Ulcers N/A
Completed NCT01348581 - Use of Fish Skin Extracellular Matrix (ECM) to Facilitate Chronic Wound Healing N/A
Completed NCT06280053 - HealiAid in the Treatment of Different Wounds N/A
Completed NCT02364921 - Effectiveness of Double-layer Compression Therapy in the Healing of Chronic Venous Ulcers in Primary Health Care N/A
Suspended NCT02930499 - Effect of Hyaluronic Acid ECM on Venous Ulcers N/A
Recruiting NCT06350695 - The ROle of Compression StocKings in Heart Failure Patients N/A
Completed NCT01214980 - Split Thickness Donor Site Healing With MIST Study N/A
Terminated NCT00613808 - Safety and Efficacy of Gaseous Nitric Oxide on Venous Stasis Leg Ulcers Phase 2
Completed NCT04703569 - Effect of Compressive Therapies on the Healing of Venous Ulcers N/A
Completed NCT01509599 - Cooling Lower Leg Skin to Prevent Venous Leg Ulcers in Patients With Poor Vein Circulation Phase 1/Phase 2
Completed NCT02632695 - Physical Activity Interventions for Leg Ulcer Patients N/A
Terminated NCT02071979 - Registry Trial of the Effectiveness of Platelet Rich Plasma for Chronic Non-Healing Wounds N/A