Methicillin-resistant Staphylococcus Aureus Septicemia Clinical Trial
Official title:
The Most Appropriate Parameter Correlates With Clinical Effectiveness of Vancomycin: Trough Drug Concentration or Area Under Curve (AUC)/Minimum Inhibitory Concentration (MIC)?
The purpose of this study is to evaluate which is the most appropriate parameter correlates with clinical effectiveness of vancomycin: trough drug level or AUC/MIC.
Several studies have shown AUC/MIC to be the better pharmacokinetic-pharmacodynamic
parameter for clinical effectiveness of vancomycin. However, the 2009 consensus guideline
for vancomycin therapeutic monitoring continued to recommend trough serum concentration
monitoring in the clinical setting. In 2011, Patel et al showed that highly difference
between AUC(72-96h) and Cmin(96h). Different dosing and creatinine clearance may reach the
same trough drug level with different AUC. The investigators wonder whether trough drug
level can serve as a substitute marker for AUC and as a parameter for vancomycin therapeutic
monitoring.
In this study, the investigators will calculate AUC/MIC of vancomycin with published
formula, analyze its correlation with patient's clinical outcome and compare that with
trough drug level.
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Observational Model: Cohort, Time Perspective: Retrospective