Glycosyltion Enzymes and Function Abnormalities Clinical Trial
Official title:
Expression of Mucin Glycosylating Enzymes in Head and Neck Cancers and Its Correlation With Clinico-pathological Parameters.
Head and neck squamous cell carcinoma(HNSCC) is the fourth common malignancy in Taiwan. It accounts for 5.8% of all cancers and causes 2,463 deaths per year. Aberrant glycosylation is the hallmark of most human cancers, including HNSCC, and affects many cellular properties. This study is aimed at exploring the role of mucin glycosylating enzymes in HNSCC.
Glycosylation is the most common post-translational modification of proteins. Aberrant
glycosylation is the hallmark of most human cancers and affect many cellular properties,
including cell proliferation, apoptosis, differentiation, transformation, migration and
immune response.
Though widely explored in various human cancers, the role of mucin glycosylating enzymes in
HNSCC has not been elucidated. Our aims is to analyze the expression patterns of mucin
glycosylating enzymes in HNSCC tissues. Furthermore, we will correlate the expression levels
of mucin glycosylating enzymes with clinical characteristics of HNSCC patients.
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Observational Model: Case Control, Time Perspective: Retrospective