Osteoporosis Clinical Trial
Official title:
Determination of the RANKL/Osteoprotegerin Ratio in Patients With Systemic Lupus Erythematosus. Role in Osteoporosis and Cardiovascular Calcification
Patients with Systemic lupus erythematosus (SLE) are known to present an increased risk of
osteoporosis and cardiovascular calcification. It has also been suggested that bone
remodelling and cardiovascular calcification are regulated by the same mechanisms, but
inversely in terms of calcium deposition, as osteoporosis is often associated with
cardiovascular calcification. Inflammatory and immune factors have been implicated in these
two processes.
The role of the RANKL/OPG system in osteoclast differentiation has been elucidated over the
last ten years. RANKL induces differentiation of monocytes-macrophages into osteoclasts,
while, inversely, OPG exerts an inhibitory role by inactivating RANKL. Differentiation of
smooth muscle cells into osteoblasts in the vessel wall induces calcification, and this
phenomenon is counterbalanced by differentiation of monocytes into osteoclasts. Although the
role of the RANKL/OPG ratio in the pathogenesis of osteoporosis has now been clearly
established, its role in vascular calcification is only hypothetical at the present time.
This study will focus on patients with SLE diagnosed and followed in the Amiens University
Hospital Internal Medicine and Nephrology departments
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