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Osteoporosis, Steroid Induced clinical trials

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NCT ID: NCT03040531 Recruiting - Clinical trials for Osteoporosis, Steroid Induced

Effects of Genistein Aglycone in Glucocorticoid Induced Osteoporosis

Start date: January 19, 2017
Phase: Phase 2/Phase 3
Study type: Interventional

Prolonged glucocorticoid therapy affects bone fragility, cardiovascular health, glucidic and lipidic metabolism, thyroid and brain function. Glucocorticoid-induced osteoporosis is characterized by low bone turnover and fractures, which occur in 30-50% of patients. Glucocorticoids affect predominantly cancellous or trabecular bone, increasing the risk of vertebral fractures, which may be asymptomatic and occur early during the first months of glucocorticoid treatment. Genistein exerts biological effects by several potential mechanisms. Besides protective effects on bone loss, genistein reduces cardiovascular risk markers, improves endothelial function and ameliorates glucose and lipid metabolism. This study is aimed at demonstrating genistein efficacy in glucocorticoid-induced osteoporosis in a cohort of caucasian post-menopausal women.

NCT ID: NCT02472782 Completed - Clinical trials for Osteoporosis, Postmenopausal

Adherence to Osteoporosis Treatment and Physicians' Perception Regarding Osteoporosis Medication

IASIS
Start date: May 2015
Phase:
Study type: Observational [Patient Registry]

This is a study aiming to investigate a possible correlation between the parameters affecting the physicians' therapeutic choice with the patients' overall adherence to osteoporosis treatment. Secondary end-points include correlation between the parameters affecting the physicians' therapeutic choice and the patients' quality of life as well as the evaluation of the whole osteoporosis treatment approach of orthopedic surgeons in Greece (diagnostic means, use of diagnostic and treatment guidelines, methodology of follow - up).