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Clinical Trial Summary

By the method of multi-mode Magnetic Resonance Imaging, 5 patients with knee osteoarthritis are selected in this trial to observe the possible differences in the brain structure and function from the 5 healthy volunteers.


Clinical Trial Description

In this study, 5 patients with knee osteoarthritis and 5 healthy volunteers were selected. The degree of pain is evaluated via visual analogue pain scale (VAS). The emotional state is evaluated by Hamilton anxiety scale (HAMA) or Hamilton depression scale (HAMD). The patients and healthy volunteers who meet the include criteria are include in the research. Then the spontaneous brain electrical activity is collected by multimodal brain magnetic resonance imaging technology. The spontaneous brain electrical activity is analyzed to find the differences between knee osteoarthritis patients and healthy volunteers. Further analysis of resting brain functional connectivity and information exchange changes in multifunctional areas, in order to elaborate the central mechanism of pain and emotion modulation. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03912610
Study type Observational
Source The Third Affiliated hospital of Zhejiang Chinese Medical University
Contact Yuanyuan Wu, Doctor
Phone +86 15336871318
Email runnaway@126.com
Status Not yet recruiting
Phase
Start date May 2019
Completion date April 2022

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