Evaluation of Salivary Level of miR-155 and IL-10 in Oral Lichen Planus Patients Before and After Treatment With Topical Corticosteroid

Oral Lichen Planus Clinical Trial

Official title:

Evaluation of Salivary Levels of miR-155 and IL-10 in Oral Lichen Planus Patients Before and After Treatment With Topical Corticosteroid

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03871114
• Other study ID #: miR-155 OLP
• Status: Completed
• Start date: March 10, 2019
• Est. completion date: April 25, 2019

Study information

• Verified date: July 2019
• Source: Cairo University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Thirty patients will be recruited from the outpatient clinic of the faculty of dentistry.fifteen systemically healthy individuals with normal mucosa and fifteen atrophic/erosive oral lichen planus patients. Oral lichen planus patients will be treated with a topical steroid and miR-155 and IL-10 will be assessed in saliva before and after 4 weeks of topical steroids use

Recruitment information / eligibility

• Status: Completed
• Enrollment: 30
• Est. completion date: April 25, 2019
• Est. primary completion date: April 10, 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 30 Years to 70 Years

Eligibility

Inclusion Criteria:

• Patients clinically and histopathologically diagnosed as having atrophic/erosive OLP.

• Patients free from any other oral lesions

• cooperative patients who agrees to take the supplied medications.

• Patients who are systemically healthy

Exclusion Criteria:

• Patients suffering from any systemic disease.

• Treatment with any systemic treatment such as systemic steroids, other immunosuppressive drugs or non-steroidal anti-inflammatory drugs at least eight weeks.

• Treatment with any oral topical medications for at least four weeks prior to the study.

• Pregnant and lactating women.

Related Conditions & MeSH terms

• Lichen Planus
• Lichen Planus, Oral
• Oral Lichen Planus

Intervention

Drug:
• Triamcinolone Acetonide in orabase
treatment of OLP with topical steroid

Locations

Country	Name	City	State
Egypt	Faculty of Dentistry	Cairo

Sponsors (1)

Lead Sponsor	Collaborator
Cairo University

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Measurement of salivary levels of miR-155 in OLP before treatment	assessment of miR-155 in saliva of patients with OLP before treatment	baseline
Primary	Measurement of salivary levels of IL-10 in OLP before treatment	assessment of IL-10 in saliva of patients with OLP before treatment	baseline
Secondary	Measurement of salivary levels of miR-155 in OLP after treatment	assessment of miR-155 in saliva of patients with OLP after treatment	4 weeks
Secondary	Measurement of salivary levels of IL-10 in OLP after treatment	assessment of IL-10 in saliva of patients with OLP after treatment	4 weeks