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Pharmacological Activation of HMN for OSA — OSA12  

Obstructive Sleep Apnea Clinical Trial

Official title:
Pharmacological Activation of Hypoglossal Motor Nucleus for Obstructive Sleep Apnea

Clinical Trial Summary

Obstructive sleep apnea (OSA) is common and has major health implications but treatment options are limited. OSA patients show a marked reduction in upper airway (UA) dilator muscle activity at sleep onset and this phenomenon leads to increased collapsibility of UA compared to normal subjects. In this protocol the investigators will test the effect of LTM1201L, LTM1201LN, LTM1201LB, LTM1201LD administered before sleep on OSA phenotype traits and OSA severity during sleep.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03640052
Study type Interventional
Source Brigham and Women's Hospital
Contact
Status Completed
Phase Phase 1/Phase 2
Start date October 30, 2018
Completion date December 31, 2019
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