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The PRE-D Trial: Effect of Dapagliflozin, Metformin and Physical Activity in Pre-diabetes

Obesity Clinical Trial

Official title:
Effect of Dapagliflozin, Metformin and Physical Activity on Glucose Variability, Body Composition and Cardiovascular Risk in Pre-diabetes

Clinical Trial Summary

The overall objective is to compare the short-term (3 months) effectiveness of three glucose-lowering interventions (dapagliflozin, metformin and physical activity) on glucose variability, body composition, and cardiometabolic risk factors in overweight or obese individuals with pre-diabetes (HbA1c 5.7-6.4% / 39-47 mmol/mol).

Clinical Trial Description

Different medical therapies and lifestyle modification for the prevention of type 2 diabetes have yet to be compared head-to-head in individuals with pre-diabetes. This research project will compare different glucose-lowering interventions in overweight and obese individuals with HbA1c levels in the pre-diabetic range. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02695810
Study type Interventional
Source Steno Diabetes Center Copenhagen
Contact
Status Completed
Phase Phase 2
Start date February 24, 2016
Completion date January 13, 2019
View Details
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